PKI (6-22) amide CAS: 121932-06-7
MF: C80H130N28O24
MW: 1868.06
A synthetic peptide that acts as a protein kinase inhibitor.

PKI (6-22) amide (CAS 121932-06-7)

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备用名: PKA Inhibitor; Protein Kinase A Inhibitor Fragment 6-22 amide
应用; PKI (6-22) amide is a synthetic peptide that acts as a protein kinase inhibitor
CAS号码: 121932-06-7
纯度: ≥97%
分子量: 1868.06
分子式: C80H130N28O24
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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PKI (6-22) amide is a synthetic peptide that acts as a protein kinase inhibitor. The compound has been shown to inhibit PKA by binding to the substrate site of PKA (IC50 < 2 nM). MDA-MB231 breast cancer cell research indicates that the antiproliferative effects of PKI (6-22) amide are associated to the cAMP-PKA pathway, due to its ability to revert the effects of oxytocin.


参考文献

1. Glass, D.B., et al. 1989. J. Biol. Chem. 264: 14579-14584. PMID: 2760075
2. Cassoni, P., et al. 1997. Int. J. Cancer. 72: 340-344. PMID: 9219843
3. Liu, H., et al. 2009. Mol. Pharmacol. 76: 1290-1301. PMID: 19734321
4. Ribeiro, R.A., et al. 2010. Br J Nutr. 1-8. PMID: 20591207

物理状态 :
Solid
顺序 :
H-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2
溶解度 :
Soluble in water, and 20% acetonitrile (1 mg/ml).
保存 :
Store at -20° C
密度 :
~1.5 g/cm3 (Predicted)
IC50 :
PKA: IC50 = < 2 nM
Ki 数据 :
PKA: Ki= 2.5 nM
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
MDL 号码 :
MFCD00133792
SMILES :
[H]/N=C(\\N)/NCCC[[email protected]@H](C(=O)N[[email protected]@H](CCCN/C(=N/[H])/N)C(=O)N[[email protected]@H](CC(=O)N)C(=O)N[[email protected]@H](C)C(=O)N[[email protected]@H]([[email protected]@H](C)CC)C(=O)N)NC(=O)CNC(=O)[[email protected]]([[email protected]@H](C)O)NC(=O)[[email protected]](CCCN/C(=N/[H])/N)NC(=O)CNC(=O)[[email protected]](CO)NC(=O)[[email protected]](C)NC(=O)[[email protected]]([[email protected]@H](C)CC)NC(=O)[[email protected]](Cc1ccccc1)NC(=O)[[email protected]](CC(=O)O)NC(=O)[[email protected]](C)NC(=O)[[email protected]](Cc2ccc(cc2)O)NC(=O)[[email protected]]([[email protected]@H](C)O)N

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