PGE2 CAS: 363-24-6
MF: C20H32O5
MW: 352.47

PGE2 (CAS 363-24-6)

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PGE2 is rated 5.0 out of 5 by 1.
备用名: PGE2 also known as Prostaglandin E2; Dinoprostone; (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1oic acid; PGE2; Dinoprostone; Cervidil; 8-isoprostaglandin E2 [MeSH: 8-isoprostaglandin E2]; 7-[(1R,2R, 3R)-3-hydroxy-2-[(3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid; PGE2 [MeSH: Dinoprostone] CBiol_001945; KBioGR_000210; KBioSS_000210; Dinoprostone Prostaglandin E2; KBio2_000210; KBio2_002778
应用; PGE2 is an extremely important eicosanoid involved in neuronal, metabolic, and immune system function
CAS号码: 363-24-6
纯度: ≥98%
分子量: 352.47
分子式: C20H32O5
* 参考分析证明 大量特定数据 (包括水 含量).

Prostaglandin E2 (PGE2) is the most physiologically abundant eicosanoid, which is produced predominantly from arachidonic acid (sc-200770) by COX and PGES, and exists at some level in nearly all cell types. PGE2 acts on four different receptors termed EP1 through EP4 yielding an astounding array of biological effects. Reported effects of PGE2 include: potent vasodilation, smooth muscle relaxation, both anti- and pro-inflammatory activities, stimulates bone resorption, synergizes with LTB4, facilitates replication of AIDS virus, regulates sleep/wake cycle, demonstrates thermoregulatory action in the CNS, induces LHRH release from rat median eminence, demonstrates a protective effect on gastric mucosa, and regulates renal hemodynamics and sodium excretion.


1. Raisz, L G., et al., 1977. Effect of prostaglaidin endoperoxides and metabolites on bone resorption in vitro. Nature. 267(5611): 532-4. PMID: 876371

2. Richardson, P D., et al., 1976. The vasodilator actions of isoprenaline, histamine, prostaglandin E2, glucagon and secretin on the hepatic arterial vascular bed of the dog. British journal of pharmacology. 57(4): 581-8. PMID: 963344

3. Christman, J W., et al., 1991. Paradoxical regulation by PGE-2 on release of neutrophil chemoattractants by rat bone marrow macrophages. Prostaglandins. 41(3): 251-62. PMID: 1852897

4. Gerozissis, K., et al., 1991. Prostaglandin E2 and leukotriene C4-induced luteinizing hormone-releasing hormone release from immature and adult male rat median eminences in vitro: eicosanoid formation and binding parameters. Prostaglandins. 41(4): 345-57. PMID: 1871376

5. Long, C R., et al., 1990. Prostaglandin E2 induced changes in renal blood flow, renal interstitial hydrostatic pressure and sodium excretion in the rat. Prostaglandins. 40(6): 591-601. PMID: 2093936

6. Raud, J., et al., 1988. Enhancement of acute allergic inflammation by indomethacin is reversed by prostaglandin E2: apparent correlation with in vivo modulation of mediator release. Proceedings of the National Academy of Sciences of the United States of America. 85(7): 2315-9. PMID: 2451246

7. Archer, C B., et al., 1987. Delayed-onset synergism between leukotriene B4 and prostaglandin E2 in human skin. Prostaglandins. 33(6): 799-805. PMID: 2823313

8. Kuno, S., et al., 1986. Prostaglandin E2, a seminal constituent, facilitates the replication of acquired immune deficiency syndrome virus in vitro. Proceedings of the National Academy of Sciences of the United States of America. 83(10): 3487-90. PMID: 3010301

9. Hayaishi, O., et al., 1988. Sleep-wake regulation by prostaglandins D2 and E2. The Journal of biological chemistry. 263(29): 14593-6. PMID: 3049580

10. Kuno, S., et al., 1986. Prostaglandin E2 administered via anus causes immunosuppression in male but not female rats: a possible pathogenesis of acquired immune deficiency syndrome in homosexual males. Proceedings of the National Academy of Sciences of the United States of America. 83(8): 2682-3. PMID: 3458226

11. Miller, T A., et al., 1983. Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms. The American journal of physiology. 245(5 Pt 1): G601-23. PMID: 6195926

物理状态 :
溶解度 :
Soluble in acetone, ethanol (50 mg/ml), DMSO (50 mg/ml), water (Partly miscible), DMF (100 mg/ml), PBS, pH 7.2 (5 mg/ml), and ethyl acetate.
保存 :
Store at -20° C
熔点 :
67-69° C
沸点 :
~530.1° C at 760 mmHg (Predicted)
密度 :
~1.1 g/cm3 (Predicted)
折射率 :
n20D 1.56
光学活性 :
α20D -85.5, c = 1 in ethanol
IC50 :
MAP kinase: IC50 = 25-50 µM (rat mesangial cells)
pK值 :
pKa: 4.76
德国水公害等级 :
PubChem CID :
默克索引 :
14: 7877
MDL 号码 :
EC号码 :
Beilstein 注册 :
CCCCC[[email protected]@H](C=C[[email protected]]1[[email protected]@H](CC(=O)[[email protected]@H]1CC=CCCCC(=O)O)O)O




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PMID: # 34117376  Ramesh, P.|Lannagan, TRM.|Jackstadt, R.|Atencia Taboada, L.|Lansu, N.|Wirapati, P.|van Hooff, SR.|Dekker, D.|Pritchard, J.|Kirov, AB.|van Neerven, SM.|Tejpar, S.|Kops, GJPL.|Sansom, OJ.|Medema, JP.| et al. 2021. Cell Death Differ.

PMID: # 33675141  Yeung, SC.|Ganesan, K.|Wong, SSC.|Chung, SK.|Cheung, CW.| et al. 2021. Eur J Neurosci. 53: 3072-3092.

PMID: # 33632872  Cirone, M.|Gilardini Montani, MS.|Benedetti, R.|Piconese, S.|Pulcinelli, FM.|Timperio, AM.|Romeo, MA.|D'Orazi, G.|Masuelli, L.|Mattei, M.|Bei, R.| et al. 2021. Mol Cancer Ther.

PMID: # 31097693  Zhan, T.|Ambrosi, G.|Wandmacher, AM.|Rauscher, B.|Betge, J.|Rindtorff, N.|Häussler, RS.|Hinsenkamp, I.|Bamberg, L.|Hessling, B.|Müller-Decker, K.|Erdmann, G.|Burgermeister, E.|Ebert, MP.|Boutros, M.| et al. 2019. Nat Commun. 10: 2197.

PMID: # 29354056  Fiore, D.|Ramesh, P.|Proto, MC.|Piscopo, C.|Franceschelli, S.|Anzelmo, S.|Medema, JP.|Bifulco, M.|Gazzerro, P.| et al. 2017. Front Pharmacol. 8: 949.

PMID: # 29095955  Matsubara, S.|Shiraishi, A.|Sakai, T.|Okuda, T.|Satake, H.| et al. 2017. PLoS ONE. 12: e0187711.

PMID: # 28892080  Zhuang, X.|Zhang, H.|Li, X.|Li, X.|Cong, M.|Peng, F.|Yu, J.|Zhang, X.|Yang, Q.|Hu, G.| et al. 2017. Nat. Cell Biol. 19: 1274-1285.

PMID: # 26610166  Nilsson, M. et al. 2016. Scandinavian journal of gastroenterology. 51: 538-47.

PMID: # 27020962  Bender, BF. et al. 2016. Lab on a chip. 16: 1505-13.

PMID: # 25510471  Aijian, AP. et al. 2015. Journal of laboratory automation. 20: 283-95.

引用1 - 1025
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