Pepstatin A CAS: 26305-03-3
MF: C34H63N5O9
MW: 685.89

Pepstatin A (CAS 26305-03-3)

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Pepstatin A is rated 4.75 out of 5 by 4.
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备用名: Pepstatin A also known as Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid; Iva-Val-Val-Sta-Ala-Sta; AHMHA; 3S,4S)-4-Amino-3-hydroxy-6-methyl-heptanoic acid); Isoval-Val-Val-Sta-Ala-Sta; IHN
应用; Pepstatin A is an inhibitor of HIV-1 and aspartic proteases and can be used in the study of protease mechanisms
CAS号码: 26305-03-3
纯度: >90%
分子量: 685.89
分子式: C34H63N5O9
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Pepstatin A inhibits the aspartic proteases cathepsin D, pepsin, and renin. Additionally, Pepstatin A suppresses p53-dependent apoptosis in lymphoid cells as well as TNFα-induced apoptosis in U937 cells. Pepstatin A also efficiently inhibits HIV-1 protease and Fcγ receptor induction by IFN-γ. Pepstatin A is a bacterial-derived chemotactic pentapeptide which is irreversibly inhibits aspartic proteases. Pepstatin A is also used as a research tool in studies of protease mechanisms and biological functions.


参考文献

1. Umezawa, H., et al. 1970. J. Antibiot. 23: 259-262. PMID: 4912600

2. Deiss, L.P., et al. 1996. EMBO J. 15: 3861-3870. PMID: 8670891

3. Wu, G.S., et al. 1998. Oncogene. 16: 2177-2183. PMID: 9619826

4. Athanassakis, I., et al. 2000. Cell. Immunol. 199: 81-88. PMID: 10698617

5. Farías, M.E., et al. 2000. FEMS Microbiol. Lett. 185: 263-266. PMID: 10754258

用法 :
Effective working concentration is a 1 μM solution, stable for at least 1 day at room temperature.
物理状态 :
Solid
顺序 :
Isovaleryl-Val-Val-Sta-Ala-Sta
溶解度 :
Soluble in 10% (v/v) acetic acid in methanol (9:1 methanol:acetic acid) (1 mg/ml), ethanol (1-2 mg/ml with heat up to 60° C), DMSO (5 mg/ml), methanol (1 mg/ml), and acetic acid. Insoluble in benzene, chloroform, water, 1 M NaOH, and ether.
保存 :
Store at -20° C
熔点 :
233° C (dec.)
沸点 :
~997.6° C at 760 mmHg (Predicted)
密度 :
~1.1 g/cm3 (Predicted)
折射率 :
n20D 1.50 (Predicted)
光学活性 :
α20D -90.0±5, c = 0.5 in MeOH
pK值 :
pKa: 4.17 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
2
RTECS :
SC6155000
PubChem CID :
默克索引 :
14: 7147
MDL 号码 :
MFCD00060740
EC号码 :
247-600-0
Beilstein 注册 :
2201362
SMILES :
C[[email protected]@H](C(=O)N[[email protected]@H](CC(C)C)[[email protected]](CC(=O)O)O)NC(=O)C[[email protected]@H]([[email protected]](CC(C)C)NC(=O)[[email protected]](C(C)C)NC(=O)[[email protected]](C(C)C)NC(=O)CC(C)C)O

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引用1 - 1042

PMID: # 34029592  Gaborit, B.|Govers, R.|Altié, A.|Brunel, JM.|Morange, P.|Peiretti, F.| et al. 2021. J Biol Chem. 100818.

PMID: # 31123703  Di Rienzo, M.|Antonioli, M.|Fusco, C.|Liu, Y.|Mari, M.|Orhon, I.|Refolo, G.|Germani, F.|Corazzari, M.|Romagnoli, A.|Ciccosanti, F.|Mandriani, B.|Pellico, MT.|De La Torre, R.|Ding, H.|Dentice, M.|Neri, M.|Ferlini, A.|Reggiori, F.|Kulesz-Martin, M.|Piacentini, M.|Merla, G.|Fimia, GM.| et al. 2019. Sci Adv. 5: eaau8857.

PMID: # 30389374  Virgolini, MJ.|Feliziani, C.|Cambiasso, MJ.|Lopez, PH.|Bollo, M.| et al. 2019. Biochim Biophys Acta Mol Cell Res. 1866: 225-239.

PMID: # 29859188  Lin, YM. et al. 2018. Biochem. Biophys. Res. Commun. 503: 157-164.

PMID: # 30387075  Prado Spalm, FH. et al. 2018. Mol. Neurobiol.

PMID: # 28475412  Yin, Y.|Dang, W.|Zhou, X.|Xu, L.|Wang, W.|Cao, W.|Chen, S.|Su, J.|Cai, X.|Xiao, S.|Peppelenbosch, MP.|Pan, Q.| et al. 2018. Virulence. 9: 83-98.

PMID: # 30270174  Risi, C.|Belknap, B.|Forgacs-Lonart, E.|Harris, SP.|Schröder, GF.|White, HD.|Galkin, VE.| et al. 2018. Structure. 26: 1604-1611.e4.

PMID: # 30316909  Alcon, SP. et al. 2018. Neuroscience.

PMID: # 28378122  Gorojod, RM. et al. 2017. Arch. Toxicol.

PMID: # 27760898  Mitsui, T.|Ishida, M.|Izawa, M.|Arita, J.| et al. 2017. Endocr. J. 64: 103-115.

引用1 - 1042
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