Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Phosphodiesterases (PDEs, also designated cyclic nucleotide phosphodiesterase) are important for the downregulation of intracellular levels of the second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). The PDE1 family are calmodulin-dependent (CaM-PDE) proteins that undergo stimulation through a calcium-calmodulin complex and function to hydrolyze cAMP to 5′AMP and cGMP to 5′GMP. PDE1C (phosphodiesterase 1C), also known as HCAM3, is a widely expressed protein that has a high affinity for both cAMP and cGMP. Two isoforms, designated PDE1C1 and PDE1C2, exist due to alternative splicing at the C-terminus. While both isoforms are expressed in low levels throughout the body, PDE1C2 is expressed predominately in the brain and heart, while PDE1C1 is expressed predominately in the brain, heart and lung.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.