O-Phospho-L-serine CAS: 407-41-0
MF: C3H8NO6P
MW: 185.07
A competitive NMDA antagonist/ group III mGluR agonist.

O-Phospho-L-serine (CAS 407-41-0)

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备用名: L-2-Amino-3-hydroxypropanoic acid 3-phosphate
应用; O-Phospho-L-serine is a competitive NMDA antagonist/ group III mGluR agonist
CAS号码: 407-41-0
纯度: ≥97%
分子量: 185.07
分子式: C3H8NO6P
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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O-Phospho-L-serine is an L-AP4 (sc-200432) agonist and a competitive NMDA antagonist. O-Phospho-L-serine has affinity for mGluR-4 (type IV), but not type I, metabotropic glutamate group III receptor agonist (mGluR-4, mGluR-7, and mGluR-8). O-Phospho-L-serine also inhibits proliferation and enhances neuronal differentiation in progenitor cells.


参考文献

1. Klunk, W E., et al., 1991. L-phosphoserine, a metabolite elevated in Alzheimer's disease, interacts with specific L-glutamate receptor subtypes. Journal of neurochemistry. 56(6): 1997-2003. PMID: 1673996
2. Thomsen, C., et al., 1993. Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor. Neuroreport. 4(9): 1099-101. PMID: 8106006
3. Borodezt, K., et al., 1998. Decreased expression of the metabotropic glutamate receptor-4 gene is associated with neuronal apoptosis. Journal of neuroscience research. 53(5): 531-41. PMID: 9726424

物理状态 :
Solid
溶解度 :
Soluble in water (50 mg/ml).
保存 :
Store at 4° C
熔点 :
190° C
沸点 :
~475.36° C at 760 mmHg (Predicted)
密度 :
~1.81 g/cm3 (Predicted)
折射率 :
n20D 1.55 (Predicted)
光学活性 :
α25/D 16.05°±0.65°, c = 1 in 2 M HCl; α20/D +5°±1°, c = 2 in water
IC50 :
mGluR-4: EC5050 = 1 µM (human); Plasmodium falciparum: EC5050 >1.07 µM; mGluR-6: EC5050 = 2.7 µM (rat); PSM: IC50 = 523 µM (human)
pK值 :
pKa: 1.71 (Predicted), pKb: 11.8 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
PubChem CID :
默克索引 :
14: 7363
MDL 号码 :
MFCD00065935
EC号码 :
206-986-0
Beilstein 注册 :
1726826
SMILES :
C(C(C(=O)O)N)OP(=O)(O)O

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