Neomycin sulfate CAS: 1405-10-3
MF: C23H46N6O13•3H2SO4
MW: 908.88
A highly active antibiotic against gram-negative bacteria often used in cell culture.

Neomycin sulfate (CAS 1405-10-3)

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备用名: Neomycin B sulfate
应用; Neomycin sulfate is a highly active antibiotic against gram-negative bacteria often used in cell culture
CAS号码: 1405-10-3
分子量: 908.88
分子式: C23H46N6O133H2SO4
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Neomycin sulfate is an aminoglycoside antibiotic and calcium channel protein inhibitor. Neomycin sulfate also binds to prokaryotic ribosomes inhibiting translation and is effective against gram-positive and gram-negative bacteria. Neomycin sulfate inhibits PLC (Phospholipase C) via binding to inositol phospholipids. It also inhibits phosphatidylcholine-PLD activity and induces Ca2+ mobilization and PLA2 activation in human platelets. Neomycin sulfate inhibits DNase I induced DNA degradation.


参考文献

1. Griffin, H.D., et al. 1980. J. Neurochem. 34: 750-752. PMID: 6243700
2. Carney, D.H., et al. 1985. Cell. 42: 479-488. PMID: 2992800
3. Vergara, J., et al. 1985. Proc. Natl. Acad. Sci. U.S.A. 82: 6352-6356. PMID: 2994073
4. Nakashima, S., et al. 1987. Biochem. Biophys. Res. Commun. 146: 820-826. PMID: 3113426
5. Gabev, E., et al. 1989. Biochim. Biophys. Acta. 979: 105-112. PMID: 2537103
6. Liscovitch, M., et al. 1991. Biochem. J. 279: 319-321. PMID: 1930152
7. Woegerbauer, M., et al. 2000. J. Antibiot. 53: 276-285. PMID: 10819299

规划 :
85% Neomycin B remainder Neomycin C
物理状态 :
Solid
溶解度 :
Soluble in water (50 mg/ml), ethanol (0.10 mg/ml), methanol (0.23 mg/ml), isopropanol (0.08 mg/ml), isoamyl alcohol (0.25 mg/ml), and benzene (0.05 mg/ml). Insoluble in acetone, chloroform, and ether.
保存 :
Store at 4° C
IC50 :
phospholipase C (PLC): IC50 = 1-10 µM; phosphatidylcholine-phospholipase D: IC50 = 65 µM
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
QP4375000
PubChem CID :
默克索引 :
14: 6454
MDL 号码 :
MFCD00077833
EC号码 :
215-773-1
SMILES :
C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O

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PMID: # 31786155  Liu, Y.|Wang, Y.|Ni, Y.|Cheung, CKY.|Lam, KSL.|Wang, Y.|Xia, Z.|Ye, D.|Guo, J.|Tse, MA.|Panagiotou, G.|Xu, A.| et al. 2020. Cell Metab. 31: 77-91.e5.

PMID: # 31368236  Koh, YC.|Li, S.|Chen, PY.|Wu, JC.|Kalyanam, N.|Ho, CT.|Pan, MH.| et al. 2019. Mol Nutr Food Res. 63: e1900514.

PMID: # 28063598  Rice, TC.|Armocida, SM.|Kuethe, JW.|Midura, EF.|Jain, A.|Hildeman, DA.|Healy, DP.|Gulbins, E.|Caldwell, CC.| et al. 2017. Cell Immunol. 313: 25-31.

PMID: # 28591579  Arensdorf, AM.|Dillard, ME.|Menke, JM.|Frank, MW.|Rock, CO.|Ogden, SK.| et al. 2017. Cell Rep. 19: 2074-2087.

PMID: # 26682948  Kuethe, JW.|Armocida, SM.|Midura, EF.|Rice, TC.|Hildeman, DA.|Healy, DP.|Caldwell, CC.| et al. 2016. Shock. 45: 647-52.

PMID: # 25329052  Kim, TJ. et al. 2014. PLoS ONE. 9: e109378.

PMID: # 16461372  Matthew C. Petersen et al. 2006. Am J Physiol Heart Circ Physiol. 291: H114-H120.

PMID: # 16920925  Palmer, G. et al. 2006. J. Immunol. 177: 2899-2907.

PMID: # 15611074  Yagishita, N. et al. 2005. J. Biol. Chem. 280: 7909-7916.

PMID: # 16037393  O'Keeffe, M. et al. 2005. Blood. 106: 3457-3464.

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