N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO) CAS: 150403-88-6
MF: C7H15N3O2•HCl
MW: 209.67
An inhibitor of NOS3.

N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO) (CAS 150403-88-6)

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N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO) is rated 5.0 out of 5 by 1.
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备用名: L-NIO hydrochloride;L-Ornithine ψ-acetamidine hydrochloride
应用; N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO) is an inhibitor of NOS3
CAS号码: 150403-88-6
纯度: ≥95%
分子量: 209.67
分子式: C7H15N3O2•HCl
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO), is an inhibitor of NOS3 (nitric oxide synthase) in the vascular endothelium that can halt endothelium-dependent relaxation induced by acteylcholine and cause endothelium-dependent contraction in aortic rings. Mechanistic studies have noted that L-NIO inhibits Ca2+-dependent NOS3 (eNOS). The same experiment on rat aorta has shown L-NIO to display a capacity to induce a dose-dependent increase in mean systemic arterial blood pressure. In addition, research has shown L-NIO to be the most potent inhibitor of the neutrophil and J774 enzymes compared to its analogues L-NMMA, L-NAME, and L-NNA.


参考文献

1. Palacios, M., et al. 1989. Biochem. Biophys. Res. Commun. 165: 802-809. PMID: 2480784
2. Rees, D.D., et al. 1990. Br. J. Pharmacol. 101: 746-752. PMID: 1706208
3. McCall, T.B., et al. 1991. Br. J. Pharmacol. 102: 234-238. PMID: 1710525
4. Moore, W.M., et al. 1994. J. Med. Chem. 37: 3886-3888. PMID: 7525961

物理状态 :
Solid
溶解度 :
Soluble in water (25 mg/ml)
保存 :
Store at -20° C
熔点 :
220-222° C
折射率 :
n20D 1.54
IC50 :
Nitric oxide synthase, inducible: IC50 = 4000 nM (human); Nitric-oxide synthase, brain: IC50 = 9000 nM (human); Nitric-oxide synthase, endothelial: IC50 = 6000 nM (human); Nitric oxide synthase, inducible: IC50 = 9000 nM (Mus musculus)
Ki 数据 :
recombinant NOS: Ki= 100 nM (human); Nitric-oxide synthase, brain: Ki= 230 nM (human); Nitric oxide synthase, inducible: Ki= 340 nM (human); Nitric-oxide synthase, endothelial: Ki= 810 nM (human)
pK值 :
pKa: 2.49, pKb: 12.34
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
PubChem CID :
MDL 号码 :
MFCD00153817
SMILES :
CC(=NCCC[[email protected]@H](C(=O)O)N)N.Cl

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