Muscone CAS: 541-91-3
MF: C16H30O
MW: 238.4
A potent antiinflammatory agent, cytrochrome P-450 inducer, and apoptosis inhibitor.

Muscone (CAS 541-91-3)

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备用名: 3-Methylcyclopentadecanone; Musk ketone
应用; Muscone is a potent antiinflammatory agent, cytrochrome P-450 inducer, and apoptosis inhibitor
CAS号码: 541-91-3
纯度: ≥98%
分子量: 238.4
分子式: C16H30O
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

Muscone, originally collected from male musk deer ventral glands, is a potent antiinflammatory agent that has been reported to reduce proinflammatory cytokines in vitro. This compound has also been shown to reverse IL-1β-induced upregulation of IL-1β, TNFα, NOS2 (inducible nitric oxide synthase), Cox-2, aggrecanase 2, matrix metalloproteinase, and nitric oxide. In rat liver, Muscone has been shown to induce CYP4F3 (cytochrome P-450) and to inhibit glutamate-induced apoptosis in PC-12 cells via maintenance of mitochondral membrane potential and inhibition of intracellular Ca2+ overload. Additional studies have reported Muscone to be weakly estrogenically active in vitro.


参考文献

1. Tanaka, E., et al. 1991. Biochem. Pharmacol. 41: 472-473. PMID: 1994906
2. Bitsch, N., et al. 2002. Arch. Environ. Contam. Toxicol. 43: 257-264. PMID: 12202919
3. Lin, D.L., et al. 2004. J. Forensic Sci. 49: 1187-1193. PMID: 15568689
4. Matsuda, H., et al. 2008. Chem. Biodivers. 5: 1023-1033. PMID: 18618396
5. Sun, R., et al. 2009. Zhongguo Zhong Yao Za Zhi. 34: 1701-1704. PMID: 19873786
6. Liang, Q.Q., et al. 2010. Clin. Orthop. Relat. Res. 46: 1600-1610. PMID: 19763723

外观 :
Oil
物理状态 :
Liquid
溶解度 :
Soluble in ethanol (25 mg/mL), and acetone.
保存 :
Store at room temperature
熔点 :
~51.13° C (Predicted)
沸点 :
~329.5° C at 760 mmHg (Predicted)
密度 :
~0.8 g/mL (Predicted)
折射率 :
n20D 1.44 (Predicted)
仅供科研使用。不可用于诊断或治疗。
RTECS :
GY0950000
PubChem CID :
MDL 号码 :
MFCD00211114
EC号码 :
208-795-8
SMILES :
CC1CCCCCCCCCCCCC(=O)C1

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PMID: # 21856397  Wu, Q. et al. 2011. Journal of ethnopharmacology. 138: 34-9.

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