MCP-3 Antibody (500-M73): sc-57364
- MCP-3 Antibody (500-M73) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against recombinant MCP-3 of human origin
- recommended for detection of MCP-3 of human origin by ELISA
- See MCP-1-4/eotaxin (B-2): sc-377082 for MCP-3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MCP-3 Antibody (500-M73). This work is in progress.
MCP-3 Antibody (500-M73) is a mouse monoclonal IgG1 antibody that detects MCP-3 in human samples through enzyme-linked immunosorbent assay (ELISA). MCP-3, also known as CCL7, plays a crucial role in the immune response by acting as a chemokine that attracts various immune cells to sites of inflammation or injury. MCP-3 is primarily secreted by activated T lymphocytes, monocytes, and fibroblasts, and MCP-3′s ability to recruit a diverse array of immune cells, including monocytes, dendritic cells, and lymphocytes, is vital for orchestrating effective immune responses. The structure of MCP-3 is characterized by a unique arrangement of cysteine residues that form disulfide bonds, which are essential for stability and function. These structural features facilitate interaction with specific chemokine receptors on target cells and influence biological activity, making MCP-3 a key player in both normal immune function and pathological conditions such as asthma and chronic inflammatory diseases. Anti-MCP-3 antibody (500-M73) is an invaluable tool for researchers studying the dynamics of immune cell migration and the underlying mechanisms of inflammatory responses.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MCP-3 Antibody (500-M73) References:
- MCP-3 in inflammatory bowel disease. | Helwig, U., et al. 2000. Gut. 47: 155. PMID: 10917750
- Association analysis of monocyte chemotactic protein-3 (MCP3) polymorphisms with asthmatic phenotypes. | Park, BL., et al. 2005. J Biochem Mol Biol. 38: 77-81. PMID: 15715950
- Cross-talk between MCP-3 and TGFbeta promotes fibroblast collagen biosynthesis. | Ong, VH., et al. 2009. Exp Cell Res. 315: 151-61. PMID: 19038247
- Tumor-associated macrophage/microglia infiltration in human gliomas is correlated with MCP-3, but not MCP-1. | Okada, M., et al. 2009. Int J Oncol. 34: 1621-7. PMID: 19424580
- Co-administration of antigen with chemokine MCP-3 or MDC/CCL22 enhances DNA vaccine potency. | Xie, X., et al. 2015. Invest New Drugs. 33: 810-5. PMID: 25952465
- 3,5-Dicaffeoylquinic acid attenuates microglial activation-mediated inflammatory pain by enhancing autophagy through the suppression of MCP3/JAK2/STAT3 signaling. | Park, J., et al. 2022. Biomed Pharmacother. 153: 113549. PMID: 36076613
- MCP-3 as a prognostic biomarker for severe fever with thrombocytopenia syndrome: a longitudinal cytokine profile study. | Liu, Z., et al. 2024. Front Immunol. 15: 1379114. PMID: 38812521
- The MCP-3/Ccr3 axis contributes to increased bone mass by affecting osteoblast and osteoclast differentiation. | Kim, JH., et al. 2024. Exp Mol Med. 56: 2465-2474. PMID: 39482538
- Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3. | Ben-Baruch, A., et al. 1995. J Biol Chem. 270: 22123-8. PMID: 7545673
- Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines. | Opdenakker, G., et al. 1993. Biochem Biophys Res Commun. 191: 535-42. PMID: 8461011
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MCP-3 Antibody (500-M73) | sc-57364 | 100 µg/ml | $322.00 |