MC 1293 MF: C16H16N2O3
MW: 284.31
An inhibitor of HDAC1 and maize histone deacetylase HD2.

MC 1293

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应用; MC 1293 is an inhibitor of HDAC1 and maize histone deacetylase HD2
分子量: 284.31
分子式: C16H16N2O3
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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MC 1293 inhibits maize histone deacetylase HD2 (IC50 = 1.9 μM) and histone deacetylase 1(HDAC1, IC50 = 4.5 μM). HDACs play a major role in histone modification.


参考文献

1. Massa, S., et al., 2001. 3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors. Journal of medicinal chemistry. 44(13): 2069-72. PMID: 11405644
2. Mai, Antonello., et al., 2002. Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation. Journal of medicinal chemistry. 45(9): 1778-84. PMID: 11960489

外观 :
Powder
物理状态 :
Solid
溶解度 :
Soluble in DMSO.
保存 :
Store at -20° C
熔点 :
215.13° C (Predicted)
沸点 :
505.42° C (Predicted)
密度 :
1.19 g/cm3 (Predicted)
折射率 :
n20D 1.59 (Predicted)
IC50 :
Histone deacetylase HD2: IC50 = 1.9 µM (Zea mays); Histone deacetylse: IC50 = 1.9 µM (human); Histone deacetylase 1: IC50 = 4.5 µM (mouse)
pK值 :
pKa: 8.89 (Predicted)
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
MDL 号码 :
MFCD04036984
SMILES :
CC1=CC=C(C=C1)C(=O)C2=CN(C(=C2)/C=C/C(=O)NO)C

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分析证明书

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引用1 - 11

PMID: # 28609444  Murata, Y. et al. 2017. PLoS ONE. 12: e0178203.

引用1 - 11
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