MAG Antibody (G-11): sc-166780
- MAG Antibody (G-11) is a mouse monoclonal IgG2b κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-300 mapping near the N-terminus of MAG of human origin
- recommended for detection of MAG of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG2b BP-HRP is the preferred secondary detection reagent for MAG Antibody (G-11) for WB and IHC(P) applications. This reagent is now offered in a bundle with MAG Antibody (G-11) (see ordering information below).
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SEE ALSO...
MAG Antibody (G-11) is a mouse monoclonal IgG2b antibody that detects myelin-associated glycoprotein (MAG) in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). MAG is a crucial cell-surface adhesion protein in the nervous system, primarily located on the surface of myelinating glial cells, where MAG plays a vital role in the interaction between glial cells and neuronal axons. This localization facilitates the formation and maintenance of myelin sheaths, which are essential for proper conduction of electrical impulses along axons. By linking glial cells to axons, MAG (G-11) antibody supports the structural integrity of the nervous system and contributes to the regulation of axonal growth and repair. MAG has been shown to inhibit axonal outgrowth, a function counteracted by neurotrophins such as brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF), which enhance neuronal survival and promote regeneration. Anti-MAG antibody (G-11) serves as an invaluable tool for researchers studying myelination, neuronal development, and mechanisms underlying neurodegenerative diseases.
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MAG Antibody (G-11) References:
- Myelin-associated glycoprotein protects neurons from excitotoxicity. | Lopez, PH., et al. 2011. J Neurochem. 116: 900-8. PMID: 21214567
- Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder. | Lossos, A., et al. 2015. Brain. 138: 2521-36. PMID: 26179919
- Structural basis of myelin-associated glycoprotein adhesion and signalling. | Pronker, MF., et al. 2016. Nat Commun. 7: 13584. PMID: 27922006
- Myelin-Associated Glycoprotein Inhibits Schwann Cell Migration and Induces Their Death. | Chaudhry, N., et al. 2017. J Neurosci. 37: 5885-5899. PMID: 28522736
- Myelin-associated glycoprotein inhibits neurite outgrowth through inactivation of the small GTPase Rap1. | Nikulina, E., et al. 2020. FEBS Lett. 594: 1389-1402. PMID: 31985825
- Myelin-associated glycoprotein combined with chitin conduit inhibits painful neuroma formation after sciatic nerve transection. | Pi, W., et al. 2022. Neural Regen Res. 17: 1343-1347. PMID: 34782580
- Myelin-associated glycoprotein activation triggers glutamate uptake by oligodendrocytes in vitro and contributes to ameliorate glutamate-mediated toxicity in vivo. | Vivinetto, AL., et al. 2022. Biochim Biophys Acta Mol Basis Dis. 1868: 166324. PMID: 34954343
- Myelin-associated glycoprotein alters the neuronal secretome and stimulates the release of TGFβ and proteins that affect neural plasticity. | Stewart, VD., et al. 2022. FEBS Lett. 596: 2952-2973. PMID: 36102862
- A novel cell-based immunofluorescence assay for the detection of autoantibodies to myelin-associated glycoprotein. | Mariotto, S., et al. 2023. Front Neurol. 14: 1289810. PMID: 38169815
- Myelin-associated glycoprotein in development and disease. | Quarles, RH. Dev Neurosci. 6: 285-303. PMID: 6085570
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MAG Antibody (G-11) | sc-166780 | 200 µg/ml | $322.00 | |||
MAG Antibody (G-11): m-IgG2b BP-HRP Bundle | sc-548530 | 200 µg Ab; 10 µg BP | $361.00 |