Lumefantrine CAS: 82186-77-4
Lumefantrine is an antimalarial which inhibits hemozoin formation.

Lumefantrine (CAS 82186-77-4)

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备用名: Benflumetol, CPG-56695
应用; Lumefantrine is an antimalarial which inhibits hemozoin formation
CAS号码: 82186-77-4
分子量: 528.94
分子式: C30H32Cl3NO
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Lumefantrine is an antimalarial which inhibits hemozoin formation.


参考文献

1. Kumar, N., et al., 1990. Stage-specific gametocytocidal effect in vitro of the antimalaria drug qinghaosu on Plasmodium falciparum. Parasitology research. 76(3): 214-8. PMID: 2179946

2. Chotivanich, K., et al., 2000. The mechanisms of parasite clearance after antimalarial treatment of Plasmodium falciparum malaria. The Journal of infectious diseases. 182(2): 629-33. PMID: 10915102

3. Mutabingwa, Theonest K., et al., . Amodiaquine alone, amodiaquine+sulfadoxine-pyrimethamine, amodiaquine+artesunate, and artemether-lumefantrine for outpatient treatment of malaria in Tanzanian children: a four-arm randomised effectiveness trial. Lancet. 365(9469): 1474-80. PMID: 15850631

物理状态 :
Solid
溶解度 :
Soluble in methanol, chloroform, DMSO (≥20 mg/ml), and water (slightly).
保存 :
Store at room temperature
熔点 :
129-132° C
沸点 :
~642.5° C at 760 mmHg (Predicted)
密度 :
~1.3 g/cm3 (Predicted)
折射率 :
n20D 1.63 (Predicted)
pK值 :
pKa: 13.44 (Predicted), pKb: 8.71 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
PubChem CID :
默克索引 :
14: 5597
MDL 号码 :
MFCD05662268
Beilstein 注册 :
8811003
SMILES :
CCCCN(CCCC)CC(C1=CC(=CC\\2=C1C3=C(/C2=C/C4=CC=C(C=C4)Cl)C=C(C=C3)Cl)Cl)O

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PMID: # 31913089  J. Biomol. Struct. Dyn. 1-12.

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