KN-62 CAS: 127191-97-3
MF: C38H35N5O6S2
KN-62 is a potent and selective inhibitor of CaMKII.

KN-62 (CAS 127191-97-3)

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备用名: 1-[N,O-Bis(5-Isoquinolinesulfonyl)-N-Methyltyrosyl]-4-Phenylpiperazine
应用; KN-62 is a potent and selective inhibitor of CaMKII
CAS号码: 127191-97-3
纯度: ≥95%
分子量: 721.84
分子式: C38H35N5O6S2
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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KN-62 has demonstrated potent and selective inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII; Ki=0.9 μM) which causes cells to arrest in the S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 μM of KN-62 blocked CaMKII phosphorylation of III-AC, and inhibited hormone-stimulated Ca2+ oscillations. Additionally, KN-62 is a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM).


参考文献

1. Tokumitsu, H., et al. 1990. J. Biol. Chem. 265: 4315-4320. PMID: 2155222
2. Minami, H., et al. 1994. Biochem. Biophys. Res. Commun. 199: 241-248. PMID: 8123019
3. Wei, J., et al. 1996. J. Biol. Chem. 271: 24231-24235. PMID: 8798667

用法 :
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.
物理状态 :
Solid
溶解度 :
Soluble in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (0.93 mg/ml), methanol (10 mg/ml), DMSO (12 mg/ml), chloroform (20 mg/ml), ethanol (~1 mg/ml), 1:2 DMF:PBS (pH 7.2) (~0.3 mg/ml), and DMF & DMSO (~30 mg/ml).
保存 :
Store at -20° C
熔点 :
130° C
沸点 :
~964.7° C at 760 mmHg (Predicted)
密度 :
~1.4 g/cm3 (Predicted)
折射率 :
n20D 1.69
IC50 :
CaM kinase II : IC50 = 0.9 µM; P2X7 receptor: IC50 = 15 nM
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
NX4899725
PubChem CID :
MDL 号码 :
MFCD00083180
SMILES :
CN([[email protected]@H](CC1=CC=C(C=C1)OS(=O)(=O)C2=CC=CC3=C2C=CN=C3)C(=O)N4CCN(CC4)C5=CC=CC=C5)S(=O)(=O)C6=CC=CC7=C6C=CN=C7

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PMID: # 24372548  Rossi, C. et al. 2014. Eur. J. Clin. Invest. 44: 295-302.

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PMID: # 22311299  Hurtado-Carneiro V. et al. 2012. Mol Neurobiol. 45(2): 348-361.

PMID: # 18577589  Wayman, GA. et al. 2008. Proc. Natl. Acad. Sci. U.S.A. 105: 9093-9098.

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