ILT-4/5 抗体 (F-7): sc-390287

ILT-4/5 Antibody (F-7) is a high quality monoclonal ILT-4/5 antibody (also designated ILT-4/5 antibody) suitable for the detection of the ILT-4/5 protein of human origin. ILT-4/5 Antibody (F-7) is available as the non-conjugated anti-ILT-4/5 antibody. Leukocyte immunoglobulin-like receptors (ILTs, also known as LIRs) are members of the immunoglobulin superfamily of glycoproteins and are predominantly expressed by monocytes, B cells, dendritic cells, natural killer (NK) cells, peripheral blood leukocytes and tissues such as placenta, lung and liver. There are several members of the ILT family, including ILT-1, ILT-2, ILT-3, ILT-4, ILT-5, ILT-6, ILT-7, ILT-8, ILT-11, LIR-6 and LIR-8. These ILT proteins are divided into two subfamiles, namely subfamily A (ILT-1, ILT-6, ILT-7, ILT-8, ILT-11 and LIR-6) and subfamily B (ILT-2, ILT-3, ILT-4, ILT-5 and LIR-8), the former of which function as stimulating receptors and the latter of which function as inhibitory receptors. Characteristically, members of subfamily A have transmembrane regions containing a charged arginine residue through which they initiate stimulatory cascades, while members of subfamily B contain cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) through which they induce inhibitory signaling cascades.