Hypoxanthine CAS: 68-94-0
MF: C5H4N4O
MW: 136.11
A marker for energy perturbation in hypoxia/ ischemia.

Hypoxanthine (CAS 68-94-0)

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备用名: 6-Hydroxypurine; Sarcine;Purin-6-ol
应用; Hypoxanthine is a marker for energy perturbation in hypoxia/ ischemia
CAS号码: 68-94-0
纯度: ≥99%
分子量: 136.11
分子式: C5H4N4O
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Hypoxanthine can be used as a marker for energy perturbation in hypoxia/ischemia and is structurally related to 6-mercaptopurine. The compound has been used in studies as in indicator, along with uric acid (sc-213135) and allantoin (sc-207271), of in vivo free radical reactions. To understand its biological implications, hypoxanthine has been used in DNA studies to investigate the destabilizing effect it has on DNA duplexes containing hypoxanthine as a base, in a gas phase versus a liquid phase. Hypoxanthine has also been used in studies along with 8-oxoguanine nucleotides to investigate their interaction with human DNA pol α (DNA polymerase alpha) and DNA polymerase I from Bacillus stearothermophilus.


参考文献

1. Marklund, N., et al. 2000. Acta Neurochir. 142: 1135-1141. PMID: 11129536
2. Patro, J.N., et al. 2009. Biochemistry. 48: 8271-8278. PMID: 19642651
3. Malináková, K., et al. 2010. J Phys Chem A. 114: 1985-1995. PMID: 20055404
4. Sun, X. and Lee, J.K. 2010. J. Org. Chem. 75: 1848-1854. PMID: 20184296

用法 :
Sterilize by filtration through a 0.22 µm filter.
外观 :
Powder
物理状态 :
Solid
溶解度 :
Does not mix appreciably with water (1:1400). Small octahedra crystals from water.
保存 :
Store at room temperature
熔点 :
>300° C
仅供科研使用。不可用于诊断或治疗。
RTECS :
UP0791000
PubChem CID :
790
默克索引 :
14: 4869
MDL 号码 :
MFCD00005725
Beilstein 注册 :
2081
SMILES :
C1=NC2=C(N1)C(=O)N=CN2

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引用1 - 22

PMID: # 15811855  Druzhyna, NM. et al. 2005. J. Biol. Chem. 280: 21673-21679.

PMID: # 15452132  Jana, A. et al. 2004. J. Biol. Chem. 279: 51451-51459.

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