Hymenidin CAS: 107019-95-4
MF: C11H12BrN5O
MW: 310.2
An antagonist of serotonergic receptors and inhibitor of CDK5/p25 and GSK-3β.

Hymenidin (CAS 107019-95-4)

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备用名: 2-Debromooroidin
应用; Hymenidin is an antagonist of serotonergic receptors and inhibitor of CDK5/p25 and GSK-3β
CAS号码: 107019-95-4
纯度: ≥95%
分子量: 310.2
分子式: C11H12BrN5O
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Hymenidin is an antagonist of serotonergic receptors and has antiprotozoal activity. Additionally, hymenidin inhibits Cdk5/p35 (IC50 = 4 μM) and GSK-3β (IC50 = 12 μM).


参考文献

1. Kobayashi, J., et al., 1986. A novel antagonist of serotonergic receptors, hymenidin, isolated from the Okinawan marine sponge Hymeniacidon sp. Experientia. 42(10): 1176-7. PMID: 3770140
2. Meijer, L., et al., 2000. Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent. Chemistry & biology. 7(1): 51-63. PMID: 10662688
3. Bickmeyer, Ulf., et al., 2004. Brominated pyrrole alkaloids from marine Agelas sponges reduce depolarization-induced cellular calcium elevation. Toxicon : official journal of the International Society on Toxinology. 44(1): 45-51. PMID: 15225561

物理状态 :
Solid
来源于 :
<i>Stylissa sp.</i>
溶解度 :
Soluble in DMSO, and 100% ethanol.
保存 :
Store at -20° C
熔点 :
249.17° C (Predicted)
沸点 :
578.30° C (Predicted)
密度 :
1.69 g/cm3 (Predicted)
折射率 :
n20D 1.74 (Predicted)
IC50 :
Cdk5/p35: IC50 = 4 µM; GSK-3β: IC50 = 12 µM; Plasmodium f.: IC50 = 40.43 µM; Leishmania d.: IC50 = 96.29 µM; Trypanosoma c.: IC50 = 235.65 µM
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
MDL 号码 :
MFCD08702701
SMILES :
C1=C(NC=C1Br)C(=O)NCC=CC2=CN=C(N2)N

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