GSK-3β Inhibitor I CAS: 327036-89-5
MF: C10H10N2SO2
MW: 222.26

GSK-3β Inhibitor I (CAS 327036-89-5)

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备用名: TDZD-8; 2-methyl-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione
应用; GSK-3β Inhibitor I is a thiadiazolidinone analog that acts as a highly selective, non-ATP competitive inhibitor of GSK-3β
CAS号码: 327036-89-5
纯度: 95%
分子量: 222.26
分子式: C10H10N2SO2
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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GSK-3β Inhibitor I is a thiadiazolidinone (TDZD) analog that acts as a highly selective, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM). GSK-3β Inhibitor I inhibits PKC and Flt-3 activities (IC50 = 1.4-5.5 μM and 673 nM, respectively). GSK-3β Inhibitor I does not significantly affect the activities of Cdk-1/cyclin B, CK-II, and PKA, (IC50 > 100 µM). This compound binds to the active site of GSK-3β.

物理状态 :
Solid
溶解度 :
Soluble in DMSO
保存 :
Store at 4° C
熔点 :
63-64.4° C
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
SMILES :
O=C1SN(C)C(N1CC2=CC=CC=C2)=O

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