GSK-3 Inhibitor X CAS: 740841-15-0
MF: C18H12BrN3O3
MW: 398.21
A selective GSK-3α/β inhibitor.

GSK-3 Inhibitor X (CAS 740841-15-0)

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备用名: BIO-Acetoxime; 6-Bromoindirubin-3′-acetoxime, BIA
应用; GSK-3 Inhibitor X is a selective GSK-3α/β inhibitor
CAS号码: 740841-15-0
纯度: ≥95%
分子量: 398.21
分子式: C18H12BrN3O3
补充资料: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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GSK-3 Inhibitor X is an acetoxime analog of BIO which acts as a selective GSK-3α/β inhibitor (IC50 values are 0.01, 2.4, 4.3 and 63 μM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B, respectively). GSK-3 Inhibitor X induces Wnt signaling and inhibits CD8+ T cell effector differentiation.

物理状态 :
Solid
溶解度 :
Soluble in DMSO (10 mg/ml).
保存 :
Store at 4° C
熔点 :
236.83° C (Predicted)
沸点 :
551.87° C (Predicted)
密度 :
1.69 g/cm3 (Predicted)
折射率 :
n20D 1.74 (Predicted)
IC50 :
GSK-3α/β: IC50 = 10 nM; Cdk5/p25: IC50 = 2.4 µM; Cdk2/A: IC50 = 4.3 µM; Cdk1/B: IC50 = 63 µM; Cdk4/D1: IC50 = ≥10 µM; aryl hydrocarbon receptor: EC5050 = ≥0.1 µM (yeast); aryl hydrocarbon receptor: EC5050 = 0.16 µM (mammalian)
pK值 :
pKa: 9.23 (Predicted)
仅供科研使用。不可用于诊断或治疗。
运输 :
UN 3077, Class 9, Packing group III
PubChem CID :
MDL 号码 :
MFCD09037533
SMILES :
CC(=O)ONC1=C2C=CC=CC2=NC1=C3C4=C(C=C(C=C4)Br)NC3=O

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PMID: # 26743080  Vattulainen-Collanus, S. et al. 2016. J. Cell. Sci. 129: 693-705.

PMID: # 26022506  Dzobo, K. et al. 2015. Stem cell reviews. 11: 761-73.

PMID: # 22532441  Peng, H. et al. 2012. FASEB J. 26: 3140-7.

PMID: # 27864906  Mol. Reprod. Dev. 8-18.

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