galectin-7 Antibody (D-5): sc-137086
- galectin-7 Antibody (D-5) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 77-136 mapping at the C-terminus of galectin-7 of human origin
- recommended for detection of galectin-7 of human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for galectin-7 Antibody (D-5) for WB and IHC(P) applications. These reagents are now offered in bundles with galectin-7 Antibody (D-5) (see ordering information below).
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Galectin-7 Antibody (D-5) is a mouse monoclonal IgG1 antibody that detects galectin-7 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Galectin-7 is a member of the galectin family, which consists of soluble β-galactoside-binding lectins that play crucial roles in cellular processes such as cell adhesion, apoptosis, and tumor progression. Notably, galectin-7 is primarily expressed in stratified squamous epithelium and is known for its pro-apoptotic function, acting upstream of c-Jun N-terminal kinase (JNK) activation and cytochrome c release, which are critical events in the apoptotic pathway. Regulation of galectin-7 is tightly controlled, as galectin-7 is activated by p53 and repressed by retinoic acid, highlighting its importance in maintaining cellular homeostasis and responding to stress signals. The galectin-7 gene is located on chromosome 19, and galectin-7 expression patterns and interactions with other proteins underscore its significance in various physiological and pathological processes, making anti-galectin-7 antibody (D-5) an essential tool for researchers studying apoptosis and cancer biology.
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galectin-7 Antibody (D-5) References:
- Galectin-7 Regulates Keratinocyte Proliferation and Differentiation through JNK-miR-203-p63 Signaling. | Chen, HL., et al. 2016. J Invest Dermatol. 136: 182-191. PMID: 26763438
- Galectin-7 in Epithelial Homeostasis and Carcinomas. | Advedissian, T., et al. 2017. Int J Mol Sci. 18: PMID: 29257082
- Galectin-7 Impairs Placentation and Causes Preeclampsia Features in Mice. | Menkhorst, E., et al. 2020. Hypertension. 76: 1185-1194. PMID: 32862708
- Galectin-7 downregulation in lesional keratinocytes contributes to enhanced IL-17A signaling and skin pathology in psoriasis. | Chen, HL., et al. 2021. J Clin Invest. 131: PMID: 33055419
- Towards a Better Understanding of the Relationships between Galectin-7, p53 and MMP-9 during Cancer Progression. | St-Pierre, Y. 2021. Biomolecules. 11: PMID: 34198494
- Functions and Inhibition of Galectin-7, an Emerging Target in Cellular Pathophysiology. | Sewgobind, NV., et al. 2021. Biomolecules. 11: PMID: 34827718
- Galectin-7 dysregulates renin-angiotensin-aldosterone and NADPH oxide synthase pathways in preeclampsia. | Menkhorst, E., et al. 2022. Pregnancy Hypertens. 30: 130-136. PMID: 36183583
- Galectin-7 reprograms skin carcinogenesis by fostering innate immune evasive programs. | Pinto, NA., et al. 2023. Cell Death Differ. 30: 906-921. PMID: 36693903
- Galectin-7 promotes cisplatin efficacy by facilitating apoptosis and G3BP1 degradation in cervical cancer. | Liu, C., et al. 2023. Biochem Pharmacol. 217: 115834. PMID: 37778447
- Galectin-7 Induction by EHMT2 Inhibition Enhances Immunity in Microsatellite Stability Colorectal Cancer. | Sun, L., et al. 2024. Gastroenterology. 166: 466-482. PMID: 38065340
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
galectin-7 Antibody (D-5) | sc-137086 | 200 µg/ml | $322.00 | |||
galectin-7 Antibody (D-5): m-IgG Fc BP-HRP Bundle | sc-539932 | 200 µg Ab; 10 µg BP | $361.00 | |||
galectin-7 Antibody (D-5): m-IgG1 BP-HRP Bundle | sc-541795 | 200 µg Ab; 20 µg BP | $361.00 |