Feprazone CAS: 30748-29-9
MF: C20H20N2O2
MW: 320.38
Inducer of the P-450 2B family of cytochromes.

Feprazone (CAS 30748-29-9)

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应用; Feprazone is inducer of the P-450 2B family of cytochromes
CAS号码: 30748-29-9
分子量: 320.38
分子式: C20H20N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Feprazone is a non-steroidal, anti-inflammatory compound. Feprazone is noted to be structurally similar to phenylbutazone (sc-204843; deuterium-labelled sc-219696) and has been utilized in research studies analyzing the induction of cytochrome P-450. Feprazon was also reported to induce the P450 2B family of cytochromes. Metabolization of Feprazone by CYP2B is reported to occur at two positons on the side chains of the compound through a molecular modeling of the interaction of the Feprazon and mammalian CYP2B.


参考文献

1. Smith, J.N., et al. 1990. J. Biochem. Toxicol. 5: 9-12. PMID: 2402005
2. Lewis, D.F. and Lake, B.G. 1997. Xenobiotica. 27: 443-478. PMID: 9179987

外观 :
Powder
物理状态 :
Solid
溶解度 :
Soluble in chloroform, acetone, DMF, methanol (slightly), and ethanol (slightly).
保存 :
Store at 4° C
熔点 :
156.5° C
沸点 :
437.20° C
密度 :
1.18 g/cm3
折射率 :
n20D 1.6
pK值 :
pKa: 4.06 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL 号码 :
MFCD00866063
EC号码 :
250-324-3
Beilstein 注册 :
3984862
SMILES :
CC(=CCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3)C

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