DL-2-Amino-4-phosphonobutanoic acid (AP4) CAS: 20263-07-4
MF: C4H10NO5P
MW: 183.10
An amino-acid derivative reported to block cone signals in the rat retina.

DL-2-Amino-4-phosphonobutanoic acid (AP4) (CAS 20263-07-4)

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备用名: DL-AP4; DL-2-Amino-4-phosphonobutanoic acid
应用; DL-2-Amino-4-phosphonobutanoic acid (AP4) is an amino-acid derivative reported to block cone signals in the rat retina
CAS号码: 20263-07-4
纯度: ≥99%
分子量: 183.10
分子式: C4H10NO5P
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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DL-2-Amino-4-phosphonobutanoic acid (AP4) is a broad spectrum EAA ligand and amino-acid derivative. An NMDA agonist/antagonist reported to block cone signals in the rat retina. DL-2-Amino-4-phosphonobutanoic acid (AP4) is also known to be a synaptic depressant. See separate isomers (sc-200429 and sc-200432).


参考文献

1. Evans, R.H., et al. 1979. Br. J. Pharmacol. 67: 591-603. PMID: 316343
2. Koerner, J.F., et al. 1981. Brain Res. 216: 192-198. PMID: 6266585
3. Slaughter, M.M., et al. 1981. Science. 211: 182-185. PMID: 6255566
4. Evans, R.H., et al. 1982. Br. J. Pharmacol. 75: 65-75. PMID: 7042024
5. Davies, J., et al. 1982. Brain Res. 235: 378-386. PMID: 6145492
6. Kleinrok, Z., et al. 1985. Pol J Pharmacol Pharm. 37: 575-584. PMID: 3008130
7. Collingridge, G.L., et al. 1989. Pharmacol. Rev. 41: 143-210. PMID: 2558391
8. Hansen, J.J., et al. 1990. Med Res Rev. 10: 55-94. PMID: 2153264
9. Green, D.G., et al. 2007. Vis. Neurosci. 24: 9-15. PMID: 17430605

物理状态 :
Solid
溶解度 :
Soluble in water (25 mg/ml), NaOH, dilute aqueous base, and ethanol.
保存 :
Store at room temperature
熔点 :
225-228° C
沸点 :
~491.7° C at 760 mmHg (Predicted)
密度 :
~1.6 g/cm3 (Predicted)
折射率 :
n20D 1.55 (Predicted)
IC50 :
Metabotropic glutamate receptor 8: IC50 = 5.1 nM (human); Metabotropic glutamate receptor 6: EC5050 = 280 nM (human); Metabotropic glutamate receptor 4: EC5050 = 330 nM (human)
pK值 :
pKa: 2.19 (Predicted), pKb: 9.75 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
ES7191700
PubChem CID :
MDL 号码 :
MFCD00013999
Beilstein 注册 :
2093908
SMILES :
C(CP(=O)(O)O)C(C(=O)O)N

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