Dipyrone CAS: 68-89-3
MF: C13H16N3O4S•Na
MW: 333.34
A non-steroidal antiinflammatory drug.

Dipyrone (CAS 68-89-3)

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备用名: Sulpyrine; Methampyrone
应用; Dipyrone is a non-steroidal antiinflammatory drug
CAS号码: 68-89-3
纯度: ≥98%
分子量: 333.34
分子式: C13H16N3O4S•Na
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

Dipyrone is a non-steroidal antiinflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a selective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX


参考文献

1. Hernandez-Delgadillo, G.P., et al., Morphine and dipyrone co-administration delays tolerance development and potentiates antinociception. Eur. J. Pharmacol. 469, 71-79, (2003) 2. Parada, C.A., et al., Activation of presynaptic NMDA receptors coupled to NaV1.8-resistant sodium channel C-fibers causes retrograde mechanical nociceptor sensitization. Proc. Natl. Acad. Sci. U. S. A. 100, 2923-2928, (2003) 3. Chandrasekharan, N.V., et al., COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc. Natl. Acad. Sci. U. S. A. 99, 13926-13931, (2002)

物理状态 :
Solid
保存 :
Store at 4° C
熔点 :
180° C
沸点 :
>374° C
密度 :
~650 kg/m3
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
MDL 号码 :
MFCD00020783
EC号码 :
200-694-7
SMILES :
CC1=C(C(=O)N(N1C)C2=CC=CC=C2)N(C)CS(=O)(=O)[O-].[Na+]

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