D-Ala-D-Ala CAS: 923-16-0
MF: C6H12N2O3
MW: 160.17
A biologically active peptide used for affinity chromatography and binding mechanism studies.

D-Ala-D-Ala (CAS 923-16-0)

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备用名: 2-[(2-ammoniopropanoyl)amino]propanoate; D-alanyl-D-alanine
应用; D-Ala-D-Ala is a biologically active peptide used for affinity chromatography and binding mechanism studies
CAS号码: 923-16-0
分子量: 160.17
分子式: C6H12N2O3
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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D-Ala-D-Ala is a biologically active peptide used for affinity chromatography and binding mechanism studies of antibiotics such as teicoplanin, ristocetin, and vancomycin.


参考文献

1. Quinn, Ryan K., Cianci, Amelia L., Beaudoin, Jennifer A., Sculimbrene, Bianca R., 2010. Synthesis of a D-Ala-D-Ala peptide isostere via olefin cross-metathesis and evaluation of vancomycin binding. Bioorganic & medicinal chemistry letters. 20(15): 4382-5. PMID: 20594838 2. Xie, Jian., Pierce, Joshua G., James, Robert C., Okano, Akinori., Boger, Dale L., 2011. A redesigned vancomycin engineered for dual D-Ala-D-ala And D-Ala-D-Lac binding exhibits potent antimicrobial activity against vancomycin-resistant bacteria. Journal of the American Chemical Society. 133(35): 13946-9. PMID: 21823662 3. Putty, Sandeep., Rai, Aman., Jamindar, Darshan., Pagano, Paul., Quinn, Cheryl L., Mima, Takehiko., Schweizer, Herbert P., Gutheil, William G., 2011. Characterization of d-boroAla as a novel broad-spectrum antibacterial agent targeting d-Ala-d-Ala ligase. Chemical biology & drug design. 78(5): 757-63. PMID: 21827632 4. Xie, Jian., Okano, Akinori., Pierce, Joshua G., James, Robert C., Stamm, Simon., Crane, Christine M., Boger, Dale L., 2012. Total synthesis of [Ψ[C(=S)NH]Tpg4]vancomycin aglycon, [Ψ[C(=NH)NH]Tpg4]vancomycin aglycon, and related key compounds: reengineering vancomycin for dual D-Ala-D-Ala and D-Ala-D-Lac binding. Journal of the American Chemical Society. 134(2): 1284-97. PMID: 22188323 5. Kwun, Min Jung., Novotna, Gabriela., Hesketh, Andrew R., Hill, Lionel., Hong, Hee-Jeon., 2013. In vivo studies suggest that induction of VanS-dependent vancomycin resistance requires binding of the drug to D-Ala-D-Ala termini in the peptidoglycan cell wall. Antimicrobial agents and chemotherapy. 57(9): 4470-80. PMID: 23836175

物理状态 :
Solid
保存 :
Store at -20° C
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
SMILES :

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