Clofibrate CAS: 637-07-0
MF: C12H15ClO3
MW: 242.70
A biochemical that induces cytochrome P450 IVA1 and IVA3.

Clofibrate (CAS 637-07-0)

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Clofibrate is rated 5.0 out of 5 by 1.
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应用; Clofibrate is a biochemical that induces cytochrome P450 IVA1 and IVA3
CAS号码: 637-07-0
纯度: ≥99%
分子量: 242.70
分子式: C12H15ClO3
补充资料: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

Clofibrate is a ligand agonist for PPARα (peroxisome proliferator-activated receptor α), or an inducer of cytochromes P450's CYP4A1 and CYP4A3. In studies utilizing rats treated with Clofibrate, cytochromes CYP4A1 and CYP4A3 are reported to be expressed in the liver. Further studies of CYP4A1 and CYP4A3 expression in rat liver indicated that these enzymes are able to catalyze oxidation of fatty acids and prostaglandins. Also offered as a deuterium-labelled compound, Clofibrate-d4 (sc-217930)


参考文献

1. Aoyama, T., et al. 1990. J. Lipid Res. 3: 1477-1482. PMID: 2280187
2. Brass, E.P. and Ruff, L.J. 1991. J. Pharmacol. Exp. Ther. 257: 1034-1038. PMID: 2046019
3. Yan, J., et al. 2010. Biochem. Cell Biol. 88: 957-967. PMID: 21102658

外观 :
Oil
物理状态 :
Liquid
溶解度 :
Soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), acetone, chloroform, ether, hexane, DMF (>50 mg/ml), and ethanol:PBS (1:6, pH 7.2) (0.1 mg/ml). Insoluble in water.
保存 :
Store at room temperature
沸点 :
154-156° C at 20 mmHg
密度 :
1.14 g/mL at 25° C
折射率 :
n20D 1.5
IC50 :
microsomal lipid peroxidation: IC50 = >1 µg/ml (rat); PPARα: EC5050 = 50 µM (mouse); PPARα: EC5050 = 55 µM (human); PPARγ: EC5050 = 500 µM; PPARδ: EC5050 = > 100 µM
Ki 数据 :
Fatty acid-binding protein, liver: Ki= 6.92 µM (rat)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
UE9480000
PubChem CID :
默克索引 :
14: 2377
MDL 号码 :
MFCD00000615
EC号码 :
211-277-4
Beilstein 注册 :
1913459
SMILES :
CCOC(=O)C(C)(C)OC1=CC=C(C=C1)Cl

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