Ciprofloxacin HCl CAS: 93107-08-5
MF: C17H18FN3O3•HCl
MW: 367.80

Ciprofloxacin HCl (CAS 93107-08-5)

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备用名: Ciprofloxacin HCl is also known as 3-Quiolinecarboxylic acid.
应用; Ciprofloxacin HCl is a fluoroquinolone DNA gyrase/topoisomerase-targeting antibiotic often used in cell culture.
CAS号码: 93107-08-5
纯度: ≥98%
分子量: 367.80
分子式: C17H18FN3O3•HCl
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Ciprofloxacin HCl is a highly active fluoroquinoline antibiotic effective against a broad spectrum of bacteria and mycoplasma with few known resistant strains. Ciprofloxacin HCl targets gyrases and topoisomerases inhibiting DNA unwinding. Ciprofloxacin HCl is effective at low concentrations (10 µg/ml) and can effectively eradicate mycoplasma in as little as 12 days. Ciprofloxacin HCl has been used as a plant fungicide and is an analog of Nalidixic Acid. Ciprofloxacin HCl shows a broad spectrum of antibacterial activity against gram positive and gram negative bacteria.


参考文献

1. Schmitt, K., et al. 1988. J. Immunol. Methods. 109: 17-25.PMID: 3282011

2. Wolfson, J.S., et al. 1985. Antimicrob. Agents Chemother. 28: 581-586. PMID: 3000292

3. Hooper, D.C. 2001. Emerg Infect Dis, 7: 337–341. PMID: 11294736

用法 :
Powder should be prepared in water or buffered media. To prepare a stock solution add the appropriate amount of powder to distilled deionized water while mixing. Adding water directly to the powder could result in insoluble mixtures that cannot be filtered without losing potency. After ensuring that the mixture is completely solubilized, filter sterilize. If desired, the pH may be adjusted. Concentration is suggested 5μg - 25 μg/mL with 10μg/mL most often utilized.
外观 :
Powder
物理状态 :
Solid
溶解度 :
Soluble in water, and 0.1 M NaOH.
保存 :
Store at room temperature
IC50 :
DNA topoisomerase II beta: IC50 = 0.2 ug.mL-1 (human)
pK值 :
pKa: 6.43 (Predicted), pKb: 8.68 (Predicted)
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
默克索引 :
14: 2314
MDL 号码 :
MFCD00242856
SMILES :
C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O.Cl

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PMID: # 31451506  Caton, E.|Nenortas, E.|Bakshi, RP.|Shapiro, TA.| et al. 2019. Antimicrob. Agents Chemother.

PMID: # 31835489  Wolf, S.|Frosch, T.|Popp, J.|Pletz, MW.|Frosch, T.| et al. 2019. Molecules. 24:

PMID: # 25881748  Tang Girdwood, SC. et al. 2015. Biochem. Pharmacol. 95: 227-37.

PMID: # 25690342  Ito, N. et al. 2015. Pharm. Res. 32: 2527-37.

PMID: # 26110969  Dai, J. et al. 2015. Biotechnol J. 10: 1783-91.

PMID: # 26064137  Heger, Z. et al. 2015. Electrophoresis. 36: 1256-64.

PMID: # 25105482  Perucca, P. et al. 2014. J. Photochem. Photobiol. B, Biol. 140: 57-68.

PMID: # 19048100  Brown, JN. et al. 2008. PLoS ONE. 3: -.

PMID: # 17287398  Christov, C. et al. 2007. Mol. Biol. Cell. 18: 1397-1409.

PMID: # 18006661  Funderburg, N. et al. 2007. Proc. Natl. Acad. Sci. U.S.A. 104: 18631-18635.

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