Cinoxacin CAS: 28657-80-9
MF: C12H10N2O5
MW: 262.22
An antibacterial quinolone.

Cinoxacin (CAS 28657-80-9)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 114ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
备用名: Cinoxacino; Cinoxacinum; Clinoxacin
应用; Cinoxacin is an antibacterial quinolone
CAS号码: 28657-80-9
纯度: ≥99%
分子量: 262.22
分子式: C12H10N2O5
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
loading

Cinoxacin is an antibacterial quinolone analog of oxolinic acid. The compound has been documented to block DNA synthesis through inhibition of Topo II (DNA gyrase) as well as topoisomerase IV. Cinoxacin has been observed to block both topoisomerse IV in both prokaryotic and eukaryotic cell lines. Due to the inhibiting activity of Cinoxacin the compound has displayed toxicity against eukaryotic cells. In vitro studies have shown the renal damage caused by Cinoxacin to be attributed to deposition of Cinoxacin crystals in the urinary tract.


参考文献

1. Sisca, T.S., et al. 1983. Drugs. 25: 544-569. PMID: 6347618
2. Drlica, K. and Zhao, X. 1997. Microbiol. Mol. Biol. Rev. 61: 377-392. PMID: 9293187

外观 :
Powder
物理状态 :
Solid
溶解度 :
Soluble in alka line solutions (pH 10 or more), and most polar organic solvents.. Insoluble in water.
保存 :
Store at 4° C
熔点 :
261-262° C
沸点 :
517.2° C at 760 mmHg (Predicted)
密度 :
1.6 g/cm3 (Predicted)
折射率 :
n20D 1.71 (Predicted)
IC50 :
DNA gyrase: IC50 >262.22 nM (Escherichia coli K-12); Plasmodium falciparum 3D7: IC50 = 5.01 µM; Plasmodium falciparum: IC50 = 6.31 µM; PhoP regulon: IC50 = 27.94 µM (Salmonella Typhimurium)
pK值 :
pKb: 4.33 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
2
RTECS :
JI4640000
PubChem CID :
默克索引 :
14: 2309
MDL 号码 :
MFCD00056776
EC号码 :
249-133-8
Beilstein 注册 :
1084304
SMILES :
CCN1C2=CC3=C(C=C2C(=O)C(=N1)C(=O)O)OCO3

下载SDS

分析证明书

在PDF文件上阅读,打印和批注,Adobe阅读器是必须的

Cinoxacin (CAS 28657-80-9)  产品相关文献索引

看其他用户如何应用Cinoxacin (CAS 28657-80-9).点击进入浏览PubMed条目 .

引用1 - 11

PMID: # 24401394  Byzova, NA. et al. 2014. Talanta. 119: 125-32.

引用1 - 11
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 99ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 6ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;