Chloroquine diphosphate salt CAS: 50-63-5
MF: C18H26ClN3•2H3PO4
MW: 515.87
An antimalarial compound.

Chloroquine diphosphate salt (CAS 50-63-5)

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同义词: Chloroquine diphosphate; Arechin; Avloclor; Malaquin; Tresochin
应用; An antimalarial compound
CAS号码: 50-63-5
纯度: ≥99%
分子量: 515.87
分子式: C18H26ClN32H3PO4
* 参考分析证明 大量特定数据 (包括水 含量).
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Chloroquine Phosphate is an antimalarial agent that has been discovered to have a distinct affinity for melanin. Used in the treatment of arthritis, malaria and Lupus. Chloroquine Phosphate is a substrate of MRP.


参考文献

1. Graves, P.R., et al. 2002. Mol Pharmacol. 62: 1364-1372 (2002). 2. Ono, C., et al. 2003. J Pharm Pharmcol. 55: 1647-1654 (2003).

物理状态 :
Solid
溶解度 :
Soluble in water (100 mM).
保存 :
Store at 4° C
熔点 :
200° C
折射率 :
n20D 1.59 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 4.7 nM; K562: IC50 = 31.83 nM (human); Plasmodium berghei: IC50 = 72 nM; Plasmodium falciparum K1: EC5050 = 310 nM; KB: IC50 = 600 nM (human)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
VB2450000
PubChem CID :
64927
默克索引 :
14: 2163
MDL 号码 :
MFCD00069852
EC号码 :
200-055-2
Beilstein 注册 :
4223142
SMILES :
CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O

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PMID: # 25187658  Le, NT. et al. 2014. J. Immunol. 193: 3803-15.

PMID: # 24262987  Tseng, YH. et al. 2014. Autophagy. 10: 20-31.

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