Chloramphenicol CAS: 56-75-7
MF: C11H12Cl2N2O5
MW: 323.13
A protein translation blocking antibiotic.

Chloramphenicol (CAS 56-75-7)

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备用名: Chlornitromycin; Chloromycetin; Chlorocid; Levomycetin; Halomycetin; Levomicetina
应用; Chloramphenicol is a protein translation blocking antibiotic
CAS号码: 56-75-7
纯度: ≥98%
分子量: 323.13
分子式: C11H12Cl2N2O5
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Chloramphenicol is a broad spectrum antibiotic which inhibits translation on the 50S ribosomal subunit at the peptidyltransferase step. It is usually bacteristatic and effective against a wide range of gram-positive and gram-negative organisms. Chloramphenicol exhibits anti-rickettsial activity and is also active against chlamydias of the psittacosis-lymphogranuloma group. Obtained from cultures of the soil bacterium Streptomyces venuzuelae isolated from the moon snail, Lunatia heros and produced synthetically. Useful for the selection of the bacterial CAT gene.


参考文献

1. Gottlieb, D. and Bhattacharyya, P.K. 1948. J. Bacteriol. 55: 409-417. PMID: 18902264
2. Bartz, Q.R. 1948. J. Biol. Chem. 172: 445-450. PMID: 18901162
3. Shalit, I. and Marks, M.I. 1984. Drugs. 28: 281-291. PMID: 6386425
4. Falagas, M.E., et al. 2008. Expert Rev Anti Infect Ther. 6: 593-600. PMID: 18847400
5. Hartmann, C., et al. 2010. J Med Microbiol. PMID: 20634329

用法 :
• Effective working concentration of 5 µg/ml.
外观 :
Crystalline
物理状态 :
Solid
溶解度 :
Soluble in water (2.5 g/l) at 25° C, methanol, ethanol, butanol, ethyl acetate, acetone, DMSO, and propylene glycol (150.8 mg/ml).
保存 :
Store at room temperature
熔点 :
149-152° C
沸点 :
~644.9° C at 760 mmHg (Predicted)
密度 :
~1.5 g/cm3 (Predicted)
折射率 :
n20D 1.61 (Predicted)
光学活性 :
α20/D +19°, c = 6 in ethanol
IC50 :
Staphylococcus lentus: IC50 = 2.3 µM; Xanthomonas campestris: IC50 = 3.6 µM; Staphylococcus aureus: IC50 = >250 µg/ml
Ki 数据 :
Escherichia coli: Ki= 700 nM
pK值 :
pKa: 5.5
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
AB6825000
PubChem CID :
默克索引 :
14: 2077
MDL 号码 :
MFCD00078159
EC号码 :
200-287-4
Beilstein 注册 :
2225532
SMILES :
OC[[email protected]@H](NC(=O)C(Cl)Cl)[[email protected]](O)C1=CC=C(C=C1)[N+]([O-])=O

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引用1 - 99

PMID: # 20624955  Pruitt, RN. et al. 2010. Proc. Natl. Acad. Sci. U.S.A. 107: 13467-13472.

PMID: # 20616070  Köpke, M. et al. 2010. Proc. Natl. Acad. Sci. U.S.A. 107: 13087-13092.

PMID: # 16988235  Balsara, Z. et al. 2006. Infection and Immunity. 74: 5602-5608.

PMID: # 15284440  Luker, KE. et al. 2004. Proc. Natl. Acad. Sci. U.S.A. 101: 12288-12293.

PMID: # 6943583  Blanc, H. et al. 1981. Proc. Natl. Acad. Sci. U.S.A. 78: 3789-3793.

PMID: # 329286  Shay, JW. et al. 1977. Proc. Natl. Acad. Sci. U.S.A. 74: 2461-2464.

PMID: # 4525288  Bunn, CL. et al. 1974. Proc. Natl. Acad. Sci. U.S.A. 71: 1681-1685.

PMID: # 5256419  Levine, AJ. et al. 1969. Proc. Natl. Acad. Sci. U.S.A. 62: 1226-1228.

PMID: # 16590991  Sarkissian, I. et al. 1962. Proc. Natl. Acad. Sci. U.S.A. 48: 1513-1519.

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