CDP 840 hydrochloride CAS: 162542-90-7
MF: C25H27NO2.HCl
MW: 409.95
A selective and potent inhibitor of PDE 4.

CDP 840 hydrochloride (CAS 162542-90-7)

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备用名: 4-(2-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-phenylethyl)pyridine
应用; CDP 840 hydrochloride is a selective and potent inhibitor of PDE 4
CAS号码: 162542-90-7
分子量: 409.95
分子式: C25H27NO2.HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

CDP 840 hydrochloride is a potent and selective inhibitor of phosphodiesterase 4 (PDE4) (IC50 = 12 nM). This compound competitively inhibits all PDE4 isoenzymes, which in turn prevents the cleavage of phosphodiester bonds found in secondary messenger molecules. This prolongs signal transduction and any subsequent effects.

物理状态 :
Solid
溶解度 :
Soluble in DMSO (100 mM).
保存 :
Desiccate at room temperature
折射率 :
n20D 1.59 (Predicted)
光学活性 :
α20/D +39°, c = 0.48 in ethanol
IC50 :
TNFalpha release: IC50 = 0.67 nM (human whole blood); Phosphodiesterase 4A: IC50 = 2.1 nM (human); Phosphodiesterase 4B: IC50 = 1.4 nM (human); Phosphodiesterase 4C: IC50 = 4.5 nM (human); Phosphodiesterase 4D: IC50 = 2.1 nM (human)
Ki 数据 :
Phosphodiesterase 4A: Ki= 4 nM (human); Phosphodiesterase 4B: Ki= 60 nM (human); Phosphodiesterase 4C: Ki= 60 nM (human); Phosphodiesterase 4D: Ki= 60 nM (human); [3H]rolipram displacement from PDE4 by RBA: Ki= 16 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
US7546100
PubChem CID :
9885877
SMILES :
COC1=C(C=C(C=C1)C(CC2=CC=NC=C2)C3=CC=CC=C3)OC4CCCC4

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