Cdk1/2 Inhibitor III CAS: 443798-55-8
MF: C15H13F2N7O2S2
MW: 425.44
A cell-permeable triazolo-diamine compound and ATP inhibitor.

Cdk1/2 Inhibitor III (CAS 443798-55-8)

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备用名: 5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide
应用; Cdk1/2 Inhibitor III is A cell-permeable triazolo-diamine compound and ATP inhibitor
CAS号码: 443798-55-8
纯度: >95%
分子量: 425.44
分子式: C15H13F2N7O2S2
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Cdk1/2 Inhibitor III is a cell-permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC50 = 20 nM, 35 nM and 92 nM in HCT-116, HeLa, and A375 cells, respectively). Cdk1/2 Inhibitor III acts as a highly potent, ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC50 = 600 pM and 500 pM, respectively) with selectivity over VEGF-R2 (IC50 = 32 nM), GSK-3b (IC50 = 140 nM), and a panel of eight other kinases (IC50 ≥ 1 µM)


参考文献

1. Lin, Ronghui., et al., 2005. 1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities. Journal of medicinal chemistry. 48(13): 4208-11. PMID: 15974571

物理状态 :
Solid
溶解度 :
DMSO
保存 :
Store at 4° C
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
SMILES :
C1=CC(=C(C(=C1)F)NC(=S)N2C(=NC(=N2)NC3=CC=C(C=C3)S(=O)(=O)N)N)F

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PMID: # 33602273  Kaminska, K.|Akrap, N.|Staaf, J.|Alves, CL.|Ehinger, A.|Ebbesson, A.|Hedenfalk, I.|Beumers, L.|Veerla, S.|Harbst, K.|Ehmsen, S.|Borgquist, S.|Borg, Å.|Pérez-Fidalgo, A.|Ditzel, HJ.|Bosch, A.|Honeth, G.| et al. 2021. Breast Cancer Res. 23: 26.

PMID: # 27233076  Gary, C.|Hajek, M.|Biktasova, A.|Bellinger, G.|Yarbrough, WG.|Issaeva, N.| et al. 2016. Oncotarget. 7: 38598-38611.

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