Caspase-3 Inhibitor 抑制剂 Caspase-3 Inhibitor is an inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10.

Caspase-3 Inhibitor 抑制剂 (CAS 210344-95-9)

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备用名: Z-DEVD-FMK
应用; Caspase-3 Inhibitor is an inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10
CAS号码: 210344-95-9
纯度: ≥90% (solid)
分子量: 668.66
分子式: C30H41FN4O12
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Caspase-3 inhibitor (Z-DEVD-FMK ) is a cell-permeable, potent, and irreversible inhibitor of caspase-3, caspase-6, caspase-7, caspase-8 and caspase-10. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Following use of the inhibitor, standard apoptosis assays can then be used to examine treated cells for evidence of apoptosis.
For the fluorometric determination of caspase-3 activity, the following caspase apoptosis detection kit is available from Santa Cruz: Caspase-3 Kit (sc-4263 AK).


参考文献

1. Schlegel, J. et al. 1996. J. Biol. Chem. 271(4): 1841-1844. PMID: 8567626
2. Nicholson, D.W. 1996. Nat. Biotechnol. 14(3): 297-301. PMID: 9630889
3. Masuda, Y. et al. 1997. Biochem. Biophys. Res. Commun. 234(3): 641-645. PMID: 9175767
4. Thornberry, N.A. and Lazebnik, Y. 1998. Science. 281(5381): 1312-1316. PMID: 9721091
5. Brockstedt, E., et al., 1998. The Journal of biological chemistry. 273(43): 28057-64. PMID: 9774422
6. Henshall, D C., et al., 2000. Journal of neurochemistry. 74(3): 1215-23. PMID: 10693954
7. Kugawa, F., et al., 2000. Biological & pharmaceutical bulletin. 23(8): 930-5. PMID: 10963298
8. Nagarajah, N.S. et al. 2004. Mol. Cancer. 3(1): 38. PMID: 15613236
9. Cervantes, J. et al. 2008. Cell. Microbiol. 10(1): 41-52. PMID: 17662073

用法 :
Pretreatment with an esterase is required when using with purified native or recombinant enzyme.

We recommend a final concentration of 2-10µM for inhibiting caspase activity in cell culture. The optimal doses may vary for different cells and culture conditions.
物理状态 :
Solid
顺序 :
Z-Asp(OCH3)-Glu(OCH3)-Val-Asp(OCH3)-FMK
溶解度 :
Soluble in DMSO (13.37 mg/ml).
保存 :
Store at -20° C
沸点 :
~914.2° C at 760 mmHg (Predicted)
密度 :
~1.3 g/cm3 (Predicted)
折射率 :
n20D 1.51 (Predicted)
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
SMILES :
CC(C)[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)OC)C(=O)CF)NC(=O)[[email protected]](CCC(=O)OC)NC(=O)[[email protected]](CC(=O)OC)NC(=O)OCC1=CC=CC=C1

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PMID: # 33618169  Wu, SW.|Su, CH.|Ho, YC.|Huang-Liu, R.|Tseng, CC.|Chiang, YW.|Yeh, KL.|Lee, SS.|Chen, WY.|Chen, CJ.|Li, YC.|Lee, CY.|Kuan, YH.| et al. 2021. Ecotoxicol Environ Saf. 213: 112062.

PMID: # 30904799  Zhao, W.|Li, H.|Hou, Y.|Jin, Y.|Zhang, L.| et al. 2019. World Neurosurg. 127: e346-e352.

PMID: # 31189945  Chambers, JS.|Brend, T.|Rabbitts, TH.| et al. 2019. Sci Rep. 9: 8553.

PMID: # 30795621  Nováková, J.|Talacko, P.|Novák, P.|Vališ, K.| et al. 2019. Cells. 8:

PMID: # 30692621  Choi, YJ. et al. 2019. Nat. Immunol. 20: 276-287.

PMID: # 31035052  Huang, WC.|Gu, PY.|Fang, LW.|Huang, YL.|Lin, CF.|Liou, CJ.| et al. 2019. Phytomedicine. 61: 152852.

PMID: # 30161272  Chen, XB.|Li, W.|Chu, AX.| et al. 2019. J. Cell. Biochem. 120: 470-480.

PMID: # 31313541  Bishayee, K.|Habib, K.|Sadra, A.|Huh, SO.| et al. 2019. Cell. Physiol. Biochem. 53: 258-280.

PMID: # 29670107  Parida, PK. et al. 2018. Cell Death Dis. 9: 448.

PMID: # 30131570  Lee, BS.|Kim, YS.|Kim, HJ.|Kim, DH.|Won, HR.|Kim, YS.|Kim, CH.| et al. 2018. Sci Rep. 8: 12520.

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