BML-282 MF: C17H11BrCl2N2O3
MW: 442.08
An inhibitor of ubiquitin C-terminal hydrolase L1.

BML-282

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备用名: N-(3,4-Dichlorobenzyl)-5-bromoisatin O-Acetyloxime
应用; BML-282 is an inhibitor of ubiquitin C-terminal hydrolase L1
分子量: 442.08
分子式: C17H11BrCl2N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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BML-282 is a novel, selective inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1, IC50 = 0.81 µM) over UCH-L3 (IC50 = 17 µM).


参考文献

1. Love, Kerry Routenberg., et al., 2007. Mechanisms, biology and inhibitors of deubiquitinating enzymes. Nature chemical biology. 3(11): 697-705. PMID: 17948018

物理状态 :
Solid
溶解度 :
Soluble in DMSO (5 mg/ml) with warming, and DMF (10 mg/ml) with warming.
保存 :
Store at -20° C
IC50 :
UCH-L1: IC50 = 0.81 µM; UCH-L3 : IC50 = 17 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
C1=C2C(=CC(=C1)Br)C(C(N2CC3=CC(=C(C=C3)Cl)Cl)=O)=NOC(=O)C

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