Benzylimidazole CAS: 4238-71-5
MF: C10H10N2
MW: 158.2
An inducer of various cytochrome P-450 isozymes and inhibitor of thromboxane A2 synthase.

Benzylimidazole (CAS 4238-71-5)

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应用; Benzylimidazole is an inducer of various cytochrome P-450 isozymes and inhibitor of thromboxane A2 synthase
CAS号码: 4238-71-5
纯度: ≥98%
分子量: 158.2
分子式: C10H10N2
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

Benzylimidazole is commonly used as a procarcinogenic or mutagenic compound. Benzylimidazole was found to induce various cytochrome P-450 (CYP) isozymes including, CYP1A, CYP2B1, CYP3A2 and CYP4A11. The compound has also decreased plasma triglyceride levels and has been a potent inducer of rat liver enzymes. Benzylimidazole has been observed to stimulate three distinct forms of UDP-glucuronosyltransferase in male Wistar rats. In addition, Benzylimidazole has been shown to inhibit TXA Synthase (thromboxane A2 synthase) and to have strong cardiotonic activity similar to the cardiac glycosides, including the absence of effects on rate and resistance to adrenergic beta blockers.


参考文献

1. Tuttle, R.S., et al. 1975. J. Pharmacol. Exp. Ther. 194: 624-632. PMID: 1159635
2. Lynch, T.J., et al. 1985. Biochem. Pharmacol. 34: 1515-1522. PMID: 2986650
3. Magdalou, J., et al. 1988. Biochem. Pharmacol. 37: 3297-3304. PMID: 2840913
4. Mori, Y., et al. 1993. Mutat. Res. 302: 129-133. PMID: 7684507
5. Mori, Y., et al. 2001. Mutagenesis. 16: 479-486. PMID: 11682638

物理状态 :
Solid
溶解度 :
Soluble in methanol, acetone, DMSO, ethanol, dilute acids (freely soluble), and buffers of pH>6.0 (freely soluble). Insoluble in water.
保存 :
Store at room temperature
熔点 :
68-70° C (lit.)
沸点 :
310° C (lit.)
密度 :
1.04 g/cm3 (Predicted)
折射率 :
n20D 1.58 (Predicted)
IC50 :
Cytochrome P450 11B1: IC50 = 135 nM (human); Thromboxane-A synthase: IC50 = 602 nM (human); Cytochrome P450 19A1: IC50 = 150 nM (human); Trypanosoma cruzi: EC5050 = 35 µM (Trypanosoma cruzi)
pK值 :
pKb: 6.79 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
PubChem CID :
MDL 号码 :
MFCD00005296
EC号码 :
224-200-4
Beilstein 注册 :
114571
SMILES :
C1=CC=C(C=C1)CN2C=CN=C2

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