B2 CAS: 115687-05-3
MF: C20H17CIN4O3
MW: 396.8
A cell permeable inhibitor of SIRT2 (sirtuin 2).

B2 (CAS 115687-05-3)

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应用; B2 is a cell permeable inhibitor of SIRT2 (sirtuin 2)
CAS号码: 115687-05-3
分子量: 396.8
分子式: C20H17CIN4O3
补充资料: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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B2 is a cell permeable inhibitor of SIRT2 (sirtuin 2) (IC50 = 35 μM). B2 promotes inclusion formation in cellular models of both Huntington′s disease and Parkinson′s disease. B2 prevents Huntington-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity. SIRT2 is known to deacetylate histones.


参考文献

1. Bodner, Ruth A., et al., 2006. Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington′s and Parkinson′s diseases. Proceedings of the National Academy of Sciences of the United States of America. 103(11): 4246-51. PMID: 16537516

物理状态 :
Solid
溶解度 :
Soluble in DMSO (>5 mg/ml), water (<2 mg/ml), and ethanol (10 mM).
保存 :
Store at -20° C
熔点 :
238.82° C (Predicted)
沸点 :
645.52° C at 760 mmHg (Predicted)
密度 :
1.41 g/cm3 (Predicted)
折射率 :
n20D 1.69 (Predicted)
IC50 :
SIRT2: IC50 = 35 µM (human); SIRT3: IC50 = >50 µM (human); SIRT1: IC50 = >50 µM (human)
pK值 :
pKb: 2.31 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
PubChem CID :
MDL 号码 :
MFCD02039810
SMILES :
C1CN(CCN1C2=C3C=CC=NC3=C(C=C2)[N+](=O)[O-])C(=O)C4=CC=C(C=C4)Cl

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