B2 is a cell permeable inhibitor of SIRT2 (sirtuin 2) (IC50 = 35 μM). B2 promotes inclusion formation in cellular models of both Huntington′s disease and Parkinson′s disease. B2 prevents Huntington-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity. SIRT2 is known to deacetylate histones.
1. Bodner, Ruth A., et al., 2006. Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington′s and Parkinson′s diseases. Proceedings of the National Academy of Sciences of the United States of America. 103(11): 4246-51. PMID: 16537516