Ampicillin sodium salt, cell culture grade CAS: 69-52-3
MF: C16H18N3NaO4S
MW: 371.39
A widely used cell culture antibiotic.

Ampicillin sodium salt, cell culture grade (CAS 69-52-3)

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备用名: D-(−)-α-Aminobenzylpenicillin ⋅ Na
应用; Ampicillin sodium salt, cell culture grade is a widely used cell culture antibiotic
CAS号码: 69-52-3
纯度: ≥90%
分子量: 371.39
分子式: C16H18N3NaO4S
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Ampicillin is a β-lactam antibiotic within the penicillin family. As a member of this family, Ampicillin is susceptible to β-lactamase, which hydrolyzes the β-lactam ring. This broad spectrum antibiotic is effective against gram-positive, gram-negative bacteria and anaerobic bacteria. Ampicillin is widely used in cell culture as a selective agent. As an antibiotic, Ampicillin binds to penicillin binding proteins (PBPs) on a susceptible organism and inhibits cell wall synthesis by interfering with the enzymes responsible for the formation of the organisms cell wall. After binding to the PBPs, Ampicilin acts as a structural analogue of acyl-D-alanyl-D-alanine, acylates the transpeptidase enzyme and thereby prevents the cross-linking of the peptidoglycan of the cell wall necessary for the growth of the bacterium.

Potency: ≥ 845 µg Ampicillin/mg (anhydrous)


参考文献

1. Yang, W., et al. 2001. Protein Expr. Purif. 22: 472-478. PMID: 11483011
2. Rafailidis, P.I., et al. 2007. Drugs. 67: 1829-1849. PMID: 17722953
3. Joseleau-Petit, D., et al. 2007. J. Bacteriol. 189: 6512-6520. PMID: 17586646

用法 :
100 µg/ml for cell culture usage
规划 :
≥ 845 µg Ampicillin/mg (anhydrous)
外观 :
Powder
物理状态 :
Solid
溶解度 :
Soluble in water (50 mg/ml), chloroform, and acetone (1:50).
保存 :
Store at -20° C
熔点 :
215° C
折射率 :
n20D 1.68 (Predicted)
IC50 :
Klebsiella pneumoniae: IC50 = 0.08 ug.mL-1; Staphylococcus aureus: IC50 = 0.74 ug.mL-1
Ki 数据 :
PEPT2: Ki= 1.3 mM (human); Oligopeptide transporter, kidney isoform: Ki= 1.3 mM (rat)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
2
RTECS :
XH8400000
PubChem CID :
默克索引 :
14: 586
MDL 号码 :
MFCD00064313
EC号码 :
200-708-1
Beilstein 注册 :
4119211
SMILES :
CC1([[email protected]@H](N2[[email protected]](S1)[[email protected]@H](C2=O)NC(=O)[[email protected]@H](C3=CC=CC=C3)N)C(=O)[O-])C.[Na+]

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PMID: # 19171936  Sato, I. et al. 2009. J. Biol. Chem. 284: 8042-8053.

PMID: # 11788606  Deneke, J. et al. 2002. J. Biol. Chem. 277: 10410-10419.

PMID: # 9374507  Scherzinger, E. et al. 1997. J. Biol. Chem. 272: 30228-30236.

PMID: # 7836390  Scheiffele, P. et al. 1995. J. Biol. Chem. 270: 1269-1276.

PMID: # 30530705  Clin. Cancer Res. 25: 1851-1866.

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