7-Hydroxy Methotrexate Sodium Salt CAS: 5939-37-7
7-Hydroxy Methotrexate Sodium Salt is a useful methotrexate metabolite.

7-Hydroxy Methotrexate Sodium Salt (CAS 5939-37-7)

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备用名: N-[4-[[(2,4-diamino-7,8-dihydro-7-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid, trisodium salt; 7-hydroxy MTX
应用; 7-Hydroxy Methotrexate Sodium Salt is a useful methotrexate metabolite
CAS号码: 5939-37-7
纯度: ≥95%
分子量: 539.4
分子式: C20H22N8O63Na
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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7-Hydroxy Methotrexate is the metabolite of methotrexate, a cell cycle arresting agent with varying effects. Methotrexate has been reported to arrest the cell cycle in late G1/S thus leading to the inhibition of the synthesis of DNA, RNA, thymidylates, and proteins. The main mechanism of action is reported to involve the inhibition of enzymes involved in purine metabolism which leads to the accumulation of adenosine or the suppression of intercellular adhesion molecule expression by T cells. Additionally, this compound has been observed to inhibit DHFR. Methotrexate has also been shown to modulate inflammation by promoting adenosine release or inhibiting transmethylation reactions. Methotrexate was also noted to decrease IL-1 production in adherent splenic cells.


参考文献

1. Richardson, V.B., et al. 1994. Cytogenet. Cell Genet. 66: 126-128. PMID: 8287684
2. Pittman, S.M., et al. 1994. Exp. Cell Res. 215: 263-272. PMID: 7982469
3. Huschtscha, L.I., et al. 1996. Br. J. Cancer. 73: 54-60. PMID: 8554984
4. Parker, R., et al. 2010. Postgrad Med J. 86: 208-211. PMID: 20354043
5. Fleisher, M. 1993. Ther Drug Monit. 15: 521-526. PMID: 8122287
6. Eckardt, J.R. 1996. Anticancer Drugs. 7: 41-46. PMID: 8862711
7. Cronstein, B.N. 1997. Rheum. Dis. Clin. North Am. 23: 739-755. PMID: 9361153
8. Rajagopalan, P.T., et al. 2002. Proc. Natl. Acad. Sci. U.S.A. 99: 13481-13486. PMID: 12359872
9. DiMartino, M.J., et al. 1987. Agents Actions. 21: 348-350. PMID: 3500597

物理状态 :
Solid
溶解度 :
Soluble in DMSO, Water and Ammonium Hydroxide, Water and Sodium Hydroxide
保存 :
Store at 4° C
熔点 :
>200° C (dec.)
密度 :
~1.7 g/cm3
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
SMILES :
CN(CC1=NC2=C(NC1=O)N=C(N=C2N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O

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PMID: # 26971211  Ferre-Aracil, J. et al. 2016. The Science of the total environment. 556: 70-9.

PMID: # 26660190  Schofield, RC.|Ramanathan, LV.|Murata, K.|Fleisher, M.|Pessin, MS.|Carlow, DC.| et al. 2016. Methods Mol. Biol. 1383: 213-22.

PMID: # 27814544  Isidori, M. et al. 2016. Environ. Pollut. 219: 275-287.

PMID: # 26322588  Schofield, RC. et al. 2015. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1002: 169-75.

PMID: # 25124055  Negreira, N. et al. 2014. Sci. Total Environ. 497-498: 68-77.

PMID: # 23800772  Begas, E. et al. 2014. J Chromatogr Sci. 52: 590-5.

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PMID: # 23357749  Negreira, N. et al. 2013. J Chromatogr A. 1280: 64-74.

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