3,3′-Diindolylmethane 3,3′-Diindolylmethane is an antineoplastic agent that activates Chk 2 and cytochrome p450.

3,3′-Diindolylmethane (CAS 1968-05-4)

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备用名: DIM; Plant Indole; 3,3′-Methylenediindole
应用; 3,3′-Diindolylmethane is an antineoplastic agent that activates Chk 2 and cytochrome p450
CAS号码: 1968-05-4
纯度: ≥98%
分子量: 246.31
分子式: C17H14N2
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

3,3′-Diindolylmethane is an anticancer and antineoplastic agent. 3,3′-Diindolylmethane induces apoptosis in human cancer cells. 3,3′-Diindolylmethane is also an activator of CYP (cytochrome P450) and Chk2 (checkpoint kinase 2) as well as a partial agonist of aryl hydrocarbon receptor (Ah Receptor). The compound is a dimer of indole-3-carbinol (sc-202662).


参考文献

Oligomerization of indole-3-carbinol in aqueous acid: K.R. Grose & L.F. Bjeldanes; Chem. Res. Toxicol. 5, 188 (1992) The anticarcinogen 3,3′-diindolylmethane is an inhibitor of cytochrome P-450: D.M. Stresser, et al.; J. Biochem. Toxicol. 10, 191 (1995) 3

外观 :
Powder
物理状态 :
Solid
溶解度 :
Soluble in DMSO (200 mg/ml), ethanol (50 mM), chloroform, and methanol. Insoluble in water.
保存 :
Store at -20° C
熔点 :
167° C
沸点 :
~504.2° C at 760 mmHg (Predicted)
密度 :
~1.30 g/cm3 (Predicted)
折射率 :
n20D 1.77 (Predicted)
IC50 :
Leishmania donovani: IC50 = 1.25 µM; MCF7: IC50 = 5.5 µM (human); MDA-MB-231: IC50 = 10 µM (human)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
NM0332000
PubChem CID :
MDL 号码 :
MFCD00195766
Beilstein 注册 :
223072
SMILES :
C1=CC=C2C(=C1)C(=CN2)CC3=CNC4=CC=CC=C43

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