ZM 323881 hydrochloride CAS: 324077-30-7
MF: C22H18FN3O2•HCl
MW: 411.86
A receptor tyrosine kinase inhibitor of VEGFR-2 (Flk-1), PDGFR-beta, EGFR, and FGFR1.

ZM 323881 hydrochloride (CAS 324077-30-7)

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Alternativa namn: 4-Fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]phenol Hydrochloride
Ansökan ZM 323881 hydrochloride is a receptor tyrosine kinase inhibitor of VEGFR-2 (Flk-1), PDGFR-beta, EGFR, and FGFR1
Momsregistreringsnummer :: 324077-30-7
Molecular Weight: 411.86
Molecular Formula: C22H18FN3O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

ZM 323881 hydrochloride is a potent and selective inhibitor of human Flk-1 (vascular endothelial growth factor receptor 2, VEGFR-2/KDR) activity. ZM 323881 hydrochloride inhibits VEGF-A-induced endothelial cell proliferation in vitro (IC50 = 8 nM). Selectively inhibits Flk-1 (VEGFR-2) (IC50 = 2 nM) over VEGFR-1 and a range of other receptor tyrosine kinases. ZM 323881 hydrochloride is an inhibitor of EGFR, Flg and PDGFR-β.


Konferenser

Whittles et al (2002) ZM323881, a novel inhibitor of vascular endothelial growth factor-receptor-2 tyrosine kinase activity. Microcirculation 9 513. Endo et al (2003) Selective inhibition of vascular endothelial growth factor receptor-2 (VEGFR-2) identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF. J.Recept.Signal Transduct.Res. 23 239.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (50 mM), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).
LAGRING :
Desiccate at 4° C
Refractive Index :
n20D ~1.70 (Predicted)
IC50 :
Flk-1: IC50 = 2 nM (human); VEGF-A-induced endothelial cell proliferation: IC50 = 8 nM; bFEF induced HUVEC50 cell proliferation: IC50 = 1.6 µM; EGF induced HUVEC50 cell proliferation: IC50 = 1.9 µM; erbB2: IC50 > 50 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
22624897
MDL Number :
MFCD08703130
SMILES :
CC1=CC(=C(C=C1O)NC2=NC=NC3=C2C=CC(=C3)OCC4=CC=CC=C4)F.Cl

Download SDS (MSDS)

Certificate of Analysis

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ZM 323881 hydrochloride (CAS 324077-30-7)  Produkt Citat

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Citations 1 to 1 of 1 total

PMID: # 32582693  Front Cell Dev Biol. 387.

Citations 1 to 1 of 1 total
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