Z-FA-FMK CAS: 197855-65-5
MF: C21H23FN2O4
MW: 386.42
Inhibits effector, but not initator caspases in vitro, and suppress some forms of apoptosis.

Z-FA-FMK (CAS 197855-65-5)

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Alternativa namn: Z-Phe-Ala fluoromethyl ketone
Ansökan Z-FA-FMK is inhibits effector, but not initator caspases in vitro, and suppress some forms of apoptosis
CAS Nr: 197855-65-5
Renhet: ≥95%
Molekylvikt: 386.42
Molekylär formel: C21H23FN2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Z-FA-FMK is an irreversible inhibitor of cysteine proteases, such as cathepsin B, L, and S, that do not require a P1 Asp residue. The compound has also inhibitited papain and cruzain. Z-FA-FMK has been shown to selectively inhibit effector caspase-2, caspase-3, caspase-6, and caspase-7 without affecting initiator caspase-8 and caspase-10 while showing minimal toxicity to normal mammalian cells in vitro. Due to Z-FA-FMK's effector caspase specificity, the compound has been recorded to inhibit some forms of caspase mediated apoptosis. The compound has been observed to be an effective in time dependent inactivation of cathepsin B isozymes from a number of tissues. Studies show Cathepsin B-like activity plays a role in the cascade of proteolytic cartilage destruction. Z-FA-FMK is an inhibitor of cathepsin H.


Konferenser

1. Shaw, E., et al. 1981. Meth. Enzymol. 80: 820-826. PMID: 7043207
2. Smith, R.E., et al. 1988. Anticancer Res. 8: 525-529. PMID: 3178145
3. Van Noorden, C.J., et al. 1988. J. Rheumatol. 15: 1525-1535. PMID: 3204599
4. Brömme, D., et al. 1989. Biochem. J. 264: 475-481. PMID: 2604727
5. Ahmed, N.K., et al. 1992. Biochem. Pharmacol. 44: 1201-1207. PMID: 1417942
6. Harth, G., et al. 1993. Mol. Biochem. Parasitol. 58: 17-24. PMID: 8459830
7. McGrath, M.E., et al. 1995. J. Mol. Biol. 247: 251-259. PMID: 7707373
8. Lotem, J., et al. 1996. Proc. Natl. Acad. Sci. U.S.A. 93: 12507-12512. PMID: 8901612
9. Eichhold, T.H., et al. 1997. J Pharm Biomed Anal. 16: 459-467. PMID: 9589405
10. Schotte, P., et al. 2001. J. Biol. Chem. 276: 21153-21157. PMID: 11290751
11. Guo, M., et al. 2002. J. Biol. Chem. 277: 14829-14837. PMID: 11815600
12. Lopez-Hernandez, F.J., et al. 2003. Mol. Cancer Ther. 2: 255-263. PMID: 12657720

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mM).
LAGRING :
Store at -20° C
Melting Point :
~226.14° C (Predicted)
Boiling Point :
630.54° C at 760 mmHg
Density :
1.21 g/cm3
Refractive Index :
n20D 1.55
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00883668
SMILES :
CC(C(=O)CF)NC(=O)C(CC1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2

Download SDS (MSDS)

Certificate of Analysis

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Z-FA-FMK (CAS 197855-65-5)  Produkt Citat

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Citations 1 to 10 of 18 total
Citations 1 to 10 of 18 total
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