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Z-DEVD-FMK | CAS 210344-95-9 | SCBT - Santa Cruz Biotechnology
Z-DEVD-FMK Z-DEVD-FMK is an inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10.

Z-DEVD-FMK (CAS 210344-95-9)

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Alternativa namn: Z-DEVD-FMK is also known as Caspase-3 Inhibitor.
Ansökan Z-DEVD-FMK is an inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10
CAS Nr: 210344-95-9
Renhet: ≥98%
Molekylvikt: 668.66
Molekylär formel: C30H41N4O12F
* Refer to Certificate of Analysis for lot specific data (including water content).
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Z-DEVD-FMK is a cell-permeable, irreversible inhibitor of Caspase-3/CPP32. Z-DEVD-FMK is also an irreversible inhibitor of Caspase-6, Caspase-7, caspase-8, and Caspase-10. Z-DEVD-FMK has been shown to inhibit tumor cell apoptosis.


Konferenser

1. Brockstedt, E., et al., 1998. Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3. The Journal of biological chemistry. 273(43): 28057-64. PMID: 9774422

2. Henshall, D C., et al., 2000. Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures. Journal of neurochemistry. 74(3): 1215-23. PMID: 10693954

3. Kugawa, F., et al., 2000. Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway. Biological & pharmaceutical bulletin. 23(8): 930-5. PMID: 10963298

4. Chen, X. et al. 2015. Brain Res. 1625 : 275-286. PMID: 26367448

Usage :
Stable for up to 1 year after receipt when stored at -20°C. Stock solutions should be aliquoted and stored at -20°C for up to 1 month.
Physical State :
Solid
Sequence :
Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
Solubility :
Soluble in DMSO (20 mM), and DMF.
LAGRING :
Store at -20° C
Boiling Point :
~914.2° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.51 (Predicted)
IC50 :
caspase-3 : IC50 = 130 nM
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD23380217
SMILES :
CC(C)[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)OC)C(=O)CF)NC(=O)[[email protected]](CCC(=O)OC)NC(=O)[[email protected]](CC(=O)OC)NC(=O)OCC1=CC=CC=C1

Download SDS (MSDS)

Certificate of Analysis

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Z-DEVD-FMK (CAS 210344-95-9)  Produkt Citat

See how others have used Z-DEVD-FMK (CAS 210344-95-9). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 56 total

PMID: 30692621 | SERPINB1-mediated checkpoint of inflammatory caspase activation. | Choi, YJ. et al. 2019. Nat. Immunol. 20: 276-287.

Citations 1 to 10 of 56 total
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