XL-147 derivative 1 CAS: 1349796-36-6
MF: C31H29N5O6S
MW: 599.66
A potent class I PI3K inhibitor.

XL-147 derivative 1 (CAS 1349796-36-6)

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Alternativa namn: N-[4-({3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}sulfamoyl)phenyl]-3-methoxy-4-methylbenzamide
Ansökan XL-147 derivative 1 is a potent class I PI3K inhibitor
CAS Nr: 1349796-36-6
Renhet: ≥98%
Molekylvikt: 599.66
Molekylär formel: C31H29N5O6S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

XL-147 derivative 1 is active against class I PI3K (IC50 = 39, 113, 9 and 43 nM for p110α, β, γ and δ, respectively). XL765 also inhibits DNA-PK (IC50 = 150 nM) and mTOR (IC50 = 157 nM) but not XL-147 which shows IC50 values of > 15 μM. [1] XL765 treatment results in decreased cell viability in 13 PDA cell lines in a dose-dependent manner. XL-147 derivative 1, a dual-target PI3K/mTOR inhibitor, inhibits cell growth and apoptosis in many more cell lines and at lower concentrations as compared to the PI3K-selective inhibitors XL147 and PIK90.

Physical State :
Solid
Solubility :
Soluble in DMSO (12 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and 30% PEG400/0.5% Tween80/5% propylene glycol (30 mg/ml at 25 °C).
LAGRING :
Store at -20° C
Melting Point :
248-251° C
Density :
~1.39 g/cm3 (Predicted)
Refractive Index :
n20D ~1.67 (Predicted)
IC50 :
PI3Kγ: IC50 = 9 nM; PI3Kα: IC50 = 39 nM; PI3Kδ: IC50 = 43 nM; PI3Kβ: IC50 = 113 nM; DNA-PK: IC50 = 150 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD18252649
SMILES :
CC1=C(C=C(C=C1)C(=O)NC2=CC=C(C=C2)S(=O)(=O)NC3=NC4=CC=CC=C4N=C3NC5=CC(=CC(=C5)OC)OC)OC

Download SDS (MSDS)

Certificate of Analysis

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