Vialinin A is a terphenyl compound originally isolated from the fungi T. terrestris and T. vialis. Terphenyls, in general, are recognized as strong antioxidants. Vialinin A potently inhibits the release of TNF-α (IC50 = 0.09 nM) and IL-4 (IC50 = 2.8 nM), as well as β-hexosaminidase and CCL2 (MCP-1) from IgE-stimulated RBL-2H3 mast cells. Vialinin A does not significantly increase lactate dehydrogenase release from RBL-2H3 mast cells, suggesting low cytotoxicity.
1 Radulovic, N., Quang, D.N., Hashimoto, T., et al. Terrestrins A-G: P-teraphenyl derivatives from the inedible mushroom Thelephora terrestris. Phytochem 66 1052-1059 (2005). 2 Xie, C., Koshino, H., Esumi, Y., et al. Vialinin A, a novel 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenger from an edible mushroom in china. Biosci Biotech Biochem 69(12) 2326-2332 (2005). 3 Liu, J. Natural terphenyls: Developments since 1877. Chem Rev 106 2209-2223 (2006). 4 Onose, J., Xie, C., Ye, Y.Q., et al. Vialinin A, a novel potent inhibitor of TNF-a production from RBL-2H3 cells. Biol Pharm Bull 31(5) 831-833 (2008).
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