VEGFR2 Kinase Inhibitor II CAS: 288144-20-7
MF: C17H15BrN2O
MW: 343.2
A cell permeable RTK inhibitor blocking VEGFR, FGFR, and PDGF activity..

VEGFR2 Kinase Inhibitor II (CAS 288144-20-7)

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Alternativa namn: (Z)-5-Bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one
Ansökan VEGFR2 Kinase Inhibitor II is a cell permeable RTK inhibitor blocking VEGFR, FGFR, and PDGF activity.
Momsregistreringsnummer :: 288144-20-7
Molecular Weight: 343.2
Molecular Formula: C17H15BrN2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

VEGFR2 Kinase Inhibitor II is a membrane permeant indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor [IC50 = 70 nM for Flk-1 (KDR/VEGF-R2 Kinase), 920 nM for PDGF-Rβ, 4.92 μM for p60c-src, and 13.3 μM for FGF-R1]. Inhibition by VEGFR2 Kinase Inhibitor II is suggested to be competitive with respect to ATP. Although, VEGFR2 Kinase Inhibitor II does not inhibit EGF-R kinase activity (IC50 > 100μM).


Konferenser

Sun, L., et al. 2000. J. Med. Chem. 43, 2655.

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml).
LAGRING :
Store at -20° C
IC50 :
VEGF-R2: IC50 = 70 nM; PDGF-Rβ: IC50 = 920 nM; p60c-src: IC50 = 4.92 µM; FGF-R1: IC50 = 13.3 µM; VEGF-induced cell proliferation: IC50 = 110 nM (umbilical vein endothelial cells); PDGF-induced cell proliferation: IC50 = 2.01 µM (umbilical vein endothelial cells); EGF-R kinase activity: IC50 = >100 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5329155
MDL Number :
MFCD03453583
SMILES :
C1CCC2=C(C1)C=C(N2)/C=C\\3/C4=C(C=CC(=C4)Br)NC3=O

Download SDS (MSDS)

Certificate of Analysis

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