Vandetanib CAS: 443913-73-3
MF: C22H24BrFN4O2
MW: 475.35
An antagonist of VEGFR (Flk and Flk) and EGFR families..

Vandetanib (CAS 443913-73-3)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 102ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Vandetanib is rated 5.0 out of 5 by 1.
loading
5
1
4
0
3
0
2
0
1
0
Alternativa namn: N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine
Ansökan Vandetanib is an antagonist of VEGFR (Flk and Flk) and EGFR families.
CAS Nr: 443913-73-3
Renhet: ≥98%
Molekylvikt: 475.35
Molekylär formel: C22H24BrFN4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
DISCOUNT: Bulk orders of Chemicals totaling $1,000 or more receive a 5% discount.
loading

Vandetanib is an antagonist of VEGFR (Flk and Flk) and EGFR families. Specifically inhibits kinase activity of Flk-1. Vandetanib is an inhibitor of Flt-4.


Konferenser

Bruns, C., et al.: Clin. Cancer Res., 6, 1936 (2000), Hennequin, L., et al.: J. Med. Chem., 45, 1300 (2002), Park, M., et al.: J. Biol. Chem., 278, 50624 (2003), Arao, T., et al.: Cancer Res., 64, 9101 (2004), Prueitt, R., et al.: Int. J. Cancer, 120, 796 (2007),

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in methanol, DMSO (4 mg/ml at 25° C), water (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
LAGRING :
Store at -20° C
Melting Point :
240-243° C (Predicted)
Boiling Point :
488.2-588.2° C at 760 mmHg (Predicted)
Density :
1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
VEGFR2: IC50 = 40 nM; VEGF-stimulated HUVEC50 proliferation : IC50 = 60 nM; VEGFR3: IC50 = 110 nM; EGF-stimulated HUVEC50 proliferation : IC50 = 170 nM; EGFR: IC50 = 500 nM
Ki Data :
Flk-1: Ki= 6.31 nM (human); Ret: Ki= 19.95 nM (human); c-Abl: Ki= 31.62 nM (human); Lck: Ki= 39.81 nM (human); Tyro3: Ki= 63.1 nM (human)
pK Values :
pKb: 8.92 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD07772346
SMILES :
CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 105ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 7ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;