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U-74389G is a nonglucocorticoid 21-aminosteroid that acts as a potent inhibitor of superoxide-mediated lipid peroxidation and has strong antioxidant activity. The compound has particularly strong antioxidant activity in a membranous system, and can interact with and be transported across lipid membrane models. Studies show that U-74389G can inhibit lipid peroxidation in different experimental systems such as cultured brain microvessel endothelial cells, Cu2+ treated monocytic THP1 cells, and LLC-PK1 cell layers, where F2 isoprostane production is blocked by the compound. Research indicates that cold storage with addition of U-74389G helps preserve small intestinal mucosa.
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See how others have used U-74389G. Click on the entry to view the PubMed entry .
PMID: # 7600656 Crutchley, DJ. et al. 1995. Circulation. 92: 238-243.
PMID: # 8589301 Salahudeen, A. et al. 1995. J. Am. Soc. Nephrol. 6: 1300-1303.
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