Tyrphostin AG 1433 is a specific and potent inhibitor of PDGFR-β (IC50 = 5.0 µM) and of Flk-1 (IC50 = 9.3 µM). Tyrphostin AG 1433 also acts as an angiogenesis inhibitor.
1. Strawn, L M., et al., 1996. Flk-1 as a target for tumor growth inhibition. Cancer research. 56(15): 3540-5. PMID: 8758924 2. Kroll, J., et al., 1997. The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. The Journal of biological chemistry. 272(51): 32521-7. PMID: 9405464
Soluble in DMSO. Further dilute with aqueous buffers just before use. Use fresh solutions.
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