Tyrphostin AG 1433 CAS: 168836-03-1
MF: C16H14N2O2
MW: 266.29
An inhibitor of PDGFR-β, Flk-1, and angiogenesis.

Tyrphostin AG 1433 (CAS 168836-03-1)

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Ansökan Tyrphostin AG 1433 is an inhibitor of PDGFR-β, Flk-1, and angiogenesis
Momsregistreringsnummer :: 168836-03-1
Purity: ≥95%
Molecular Weight: 266.29
Molecular Formula: C16H14N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Tyrphostin AG 1433 is a specific and potent inhibitor of PDGFR-β (IC50 = 5.0 µM) and of Flk-1 (IC50 = 9.3 µM). Tyrphostin AG 1433 also acts as an angiogenesis inhibitor.


Konferenser

1. Strawn, L M., et al., 1996. Flk-1 as a target for tumor growth inhibition. Cancer research. 56(15): 3540-5. PMID: 8758924
2. Kroll, J., et al., 1997. The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. The Journal of biological chemistry. 272(51): 32521-7. PMID: 9405464

Physical State :
Solid
Solubility :
Soluble in DMSO. Further dilute with aqueous buffers just before use. Use fresh solutions.
LAGRING :
Store at -20° C
Melting Point :
193.62° C (Predicted)
Boiling Point :
490.94° C at 760 mmHg (Predicted)
Density :
1.30 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
IC50 :
Platelet-derived growth factor receptor: IC50 = 0.6 µM (mouse); PDGFR-β: IC50 = 5.0 µM; Flk-1: IC50 = 9.3 µM
pK Values :
pKa: 8.32 (Predicted), pKb: 0.86 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
PubChem CID :
5353386
MDL Number :
MFCD03426524
SMILES :
CC1=CC2=C(C=C1C)NC(=CN2)C3=CC(=O)C(=O)C=C3

Download SDS (MSDS)

Certificate of Analysis

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