Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Tail-interacting 47kDa protein (TIP47), known also as human placental tissue protein 17b (PP17b), binds to cytoplasmic domains of the cation-dependent (CD) and cation-independent (CI) mannose 6-phosphate receptors (MPRs) and facilitates their transport from endosomes to the golgi complex. The inability of TIP47 to bind several proteins also transported from endosomes to the trans golgi network indicates that TIP47 associates with a very select set of cargo molecules. In CD-MPR, TIP47 recognizes a phenylalanine/tryptophan signal sequence essential for proper sorting within the endosomal pathway. For CI-MPR binding, TIP47 requires cytoplasmic residues 48-74 of CI-MPR for high-affinity binding while residues 75-163 of CI-MPR aid in the presentation of the higher-affinity residues. Additionally, TIP47 competes with AP-2 clathrin adaptor for binding residues 24-29 of CI-MPR. In tissue extracts of cervical carcinoma patients, TIP47 is overexpressed. Dysplastic cells in high grade dysplasias express more TIP47 than dysplastic cells in low grade dysplasias, and both cytoplasmic types of dysplasias express more TIP47 than normal cervical epithelial cells. The gene encoding human TIP47 maps to chromosome 19pter-19p13.3.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn