Sunitinib, Free Base CAS: 557795-19-4
Sunitinib, Free Base is an inhibitor of receptor tyrosine kinases.

Sunitinib, Free Base (CAS 557795-19-4)

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Alternativa namn: Sutent; sunitinibum
Ansökan Sunitinib, Free Base is an inhibitor of receptor tyrosine kinases
Momsregistreringsnummer :: 557795-19-4
Purity: ≥99%
Molecular Weight: 398.47
Molecular Formula: C22H27FN4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Sunitinib, Free Base is a free base form of Sunitinib malate salt (sc-220177) which is used for the study of imatinib-resistant gastrointestinal stromal tumor (GIST) cells. Sunitinib malate salt (sc-220177) inhibits c-KIT, Flk-1, Flt-1, Flt-3/Flt-2, Flt-4, PDGRFα, PDGFRβ, c-Fms-CSF-1R, and Ret.


Konferenser

3. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. Motzer RJ et al. N.Engl.J.Med. 356(2), 115–124 (2007)

Appearance :
Crystalline granules or crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (very poorly), DMSO (40 mg/ml), and ethanol with warming (1.4 mg/ml).
LAGRING :
Store at -20° C
Melting Point :
234-246° C
Boiling Point :
~572.1° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
c-Kit: IC50 = 0.7 nM (human); Flt-1: IC50 = 1 nM (human); PDGFR-β: IC50 = 2 nM (human); Flt-3/Flk-2: IC50 = 3 nM (human); PDGFR: IC50 = 3 nM
Ki Data :
Flk-1: Ki= 2.9 nM (human)
pK Values :
pKa: 11.7 (Predicted), pKb: 9.09 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UX9355900
PubChem CID :
5329102
MDL Number :
MFCD09260778
SMILES :
CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\\2/C3=C(C=CC(=C3)F)NC2=O)C

Download SDS (MSDS)

Certificate of Analysis

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Sunitinib, Free Base (CAS 557795-19-4)  Produkt Citat

See how others have used Sunitinib, Free Base (CAS 557795-19-4). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 28336715  Kalxdorf, M. et al. 2017. Mol. Cell Proteomics. 16: 770-785.

PMID: # 24722469  2014. Oncotarget. 5: 1955-68.

PMID: # 24073208  Sato, M. et al. 2013. PLoS ONE. 8: e74313.

Citations 1 to 3 of 3 total
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