SU11652 CAS: 326914-10-7
MF: C22H27ClN4O2
MW: 414.9
A cell-permeable pyrrole-indolinone that acts as a tyrosine kinase receptor & angiogenic inhibitor.

SU11652 (CAS 326914-10-7)

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Alternativa namn: 5-[(Z)-(5-chloro-1, 2-dihydro-2-oxo-3H-indol-3- ylidene)methyl]-N-[2-(diethylamino)ethyl]-2, 4-dimethyl-1H-pyrrole-3-carboxamide
Ansökan SU11652 is a cell-permeable pyrrole-indolinone that acts as a tyrosine kinase receptor & angiogenic inhibitor
Momsregistreringsnummer :: 326914-10-7
Purity: >97%
Molecular Weight: 414.9
Molecular Formula: C22H27ClN4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

SU11652 is a potent cell-permeable pyrrole-indolinone compound that acts as an ATP-competitive tyrosine kinase receptor and angiogenic inhibitor that exhibits greater selectivity for PDGFR-β (PDGFRβ, IC50 = 3 nM), Flk-1 (VEGFR2, IC50 = 27 nM), FGFR1 (IC50= 170 nM), and Kit family members (IC50=~10-500 nM) over EGFR (IC50 >20 μM). SU11652 displays anti-proliferative and pro-apoptotic properties in tumor cells.


Konferenser

Heryanto, B., et al. 2003. Reproduction 125, 334. Sun, L., et al. 2003. J. Med. Chem. 46, 1116. Liao, A.T., et al. 2002. Blood 100, 585.

Usage :
Following reconstitution, aliquot and freeze at -20°C. Stable for up to 6 months at -20°C.
Physical State :
Solid
Solubility :
Soluble in DMSO (>25 mg/ml).
LAGRING :
Store at 4° C
Boiling Point :
596.49° C at 760 mmHg (Predicted)
Density :
1.25 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
PDGFRβ: IC50 = 3 nM; VEGFR2: IC50 = 27 nM; FGFR1: IC50 = 170 nM; Kit family members: IC50 = ~ 10-500 nM; EGFR : IC50 = >20 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5329103
MDL Number :
MFCD09037560
SMILES :
CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\\2/C3=C(C=CC(=C3)Cl)NC2=O)C

Download SDS (MSDS)

Certificate of Analysis

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SU11652 (CAS 326914-10-7)  Produkt Citat

See how others have used SU11652 (CAS 326914-10-7). Click on the entry to view the PubMed entry .

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PMID: # 32830849  Biochem. J.

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