SU 5402 CAS: 215543-92-3
MF: C17H16N2O3
SU 5402 is a FGFR-specific tyrosine kinase inhibitor.

SU 5402 (CAS 215543-92-3)

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SU 5402 is rated 5.0 out of 5 by 3.
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Alternativa namn: 3-[4-Methyl-2-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl]-propionic acid
Ansökan SU 5402 is a FGFR-specific tyrosine kinase inhibitor
Momsregistreringsnummer :: 215543-92-3
Purity: ≥97%
Molecular Weight: 296.32
Molecular Formula: C17H16N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

SU 5402 is a fibroblast growth factor receptor (FGFR)-specific tyrosine kinase inhibitor. Multiple myeloma studies suggest that SU 5402 inhibits FGFR3 phosphorylation in vitro. Research shows that inhibition of FGFR results in the blocking of nodal vesicular parcels (NVPs) secretion and an increase of Ca2+. Additionally, SU 5402 has been observed to inhibit IL-1β-induced MAPK activity.


Konferenser

1. Paterson, J.L., et al. 2004. Br. J. Haematol. 124: 595-603. PMID: 14871245
2. Tanaka, Y., et al. 2005. Nature. 435: 172-177. PMID: 15889083
3. Petersen, L.G., et al. 2006. Diabetologia. 49: 1864-1875. PMID: 16718462

Physical State :
Solid
Solubility :
Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
LAGRING :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5307
SMILES :
CC1=CNC(\\C=C2/C(=O)NC3=CC=CC=C23)=C1CCC(O)=O

Download SDS (MSDS)

Certificate of Analysis

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SU 5402 (CAS 215543-92-3)  Produkt Citat

See how others have used SU 5402 (CAS 215543-92-3). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 29 total

PMID: # 31324869  2019. Sci Rep. 9: 10494.

PMID: # 31251937  Cheng, J.|Chen, M.|Zhu, JX.|Li, CF.|Zhang, QP.|Geng, D.|Liu, Q.|Yi, LT.| et al. 2019. Biochem. Pharmacol. 168: 91-99.

PMID: # 29395614  Jiang, L.|Xu, J.|Jin, R.|Bai, H.|Zhang, M.|Yang, S.|Zhang, X.|Zhang, X.|Han, Z.|Zeng, S.| et al. 2018. Hear. Res. 361: 66-79.

PMID: # 28900173  Zhao, Q.|Parris, AB.|Howard, EW.|Zhao, M.|Ma, Z.|Guo, Z.|Xing, Y.|Yang, X.| et al. 2017. Sci Rep. 7: 11306.

PMID: # 28797129  Go, YY. et al. 2017. PLoS ONE. 12: e0182716.

PMID: # 28429746  Miura, Y.|Ngo Thai Bich, V.|Furuya, M.|Hasegawa, H.|Takahashi, S.|Katagiri, N.|Hongu, T.|Funakoshi, Y.|Ohbayashi, N.|Kanaho, Y.| et al. 2017. Sci Rep. 7: 46649.

PMID: # 27317650  Takase, N.|Koma, Y.|Urakawa, N.|Nishio, M.|Arai, N.|Akiyama, H.|Shigeoka, M.|Kakeji, Y.|Yokozaki, H.| et al. 2016. Cancer Lett. 380: 47-58.

PMID: # 26939023  Makani, V. et al. 2016. PloS one. 11: e0149715.

PMID: # 27182743  Leach, LL. et al. 2016. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 32: 317-30.

PMID: # 27443835  Gama Sosa, MA. et al. 2016. Sci Rep. 6: 30267.

Citations 1 to 10 of 29 total
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